Pretreatment with corticosteroids attenuates the efficacy of colchicine in preventing recurrent pericarditis: a multi-centre all-case analysis

European Heart Journal
Galit ArtomYehuda Adler


Effective prevention of recurrent pericarditis remains an important yet elusive goal. Corticosteroid therapy often needs to be continued for a prolonged period and causes severe side effects. We performed a multi-centre all-case analysis to investigate the efficacy of colchicine in preventing subsequent relapses of pericarditis, and addressed the hypothesis that pretreatment with corticosteroids may attenuate the beneficial effect of colchicine. One hundred and forty published and unpublished cases of patients treated with colchicine after at least two relapses of pericarditis were aggregated from European centres. Of those, 119 were included in the study group. Only 18% of the patients had relapses under colchicine therapy, and 30% after its discontinuation. There were significantly more relapses among male patients after colchicine treatment (36 vs. 17%, P=0.046), and those with previous corticosteroid treatment (43 vs. 13%, P=0.02). Multivariate logistic regression analysis identified previous corticosteroid therapy (OR 6.68, 95% CI: 1.65-27.02) and male gender (OR 4.20, 95% CI: 1.16-15.21) as independent risk factors for recurrence following colchicine therapy. Treatment with colchicine is highly effective in preventing rec...Continue Reading


Oct 1, 1990·Circulation·J GuindoA Bayés de Luna
May 1, 1994·The American Journal of Cardiology·Y AdlerY Shoenfeld
Mar 1, 1993·European Heart Journal·M P DouchetJ L Fincker
Mar 10, 1998·Clinical Cardiology·Y AdlerA Bayes de Luna
Nov 30, 2000·Current Treatment Options in Cardiovascular Medicine·S H MewarD H Spodick
Jan 25, 2002·La Revue de médecine interne·B GranelP J Weiller
Mar 8, 2003·JAMA : the Journal of the American Medical Association·David H Spodick
Aug 19, 2003·Heart·Bernhard Maisch, Arsen D Ristić

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