Pretreatment with glucose-insulin-potassium improves ventricular performances after coronary artery bypass surgery: a randomized controlled trial.

Journal of Clinical Monitoring and Computing
Marc LickerChristoph Ellenberger

Abstract

Heart failure is the main cause of poor outcome following open heart surgery and experimental studies have demonstrated that glucose-insulin-potassium (GIK) infusion exerts cardioprotective effects by reducing myocardial ischemia-reperfusion injuries. This randomized controlled trial was designed to assess the effects of GIK on left ventricular function in moderate-to-high risk patients undergoing on-pump isolated coronary artery bypass surgery (CABGS), or combined with aortic valve replacement. The primary outcomes were the effects of GIK on two- and three-dimensional left ventricular ejection fraction (2D and 3D-LVEF), and on transmitral flow propagation velocity (Vp), that occurred between the pre- and post-CPB periods. GIK administration was associated with favorable interaction effects (p < 0.001) on 2D-LVEF, 3D-LVEF and Vp changes over the study periods. In GIK pretreated patients (N = 54), 2-D and 3D-LVEF and Vp increased slightly during surgery (mean difference [MD] + 3.5%, 95% confidence interval [95% CI] - 0.2 to 7.1%, MD + 4.0%, 95% CI 0.6-7.4%, and MD + 22.2%, 95% CI 16.0-28.4%, respectively). In contrast, in the Placebo group (N = 46), 2D-and 3D-LVEF, as well as Vp all decreased after CPB (MD - 7.5% [- 11.6 to - 3....Continue Reading

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Citations

Apr 13, 2019·Journal of Clinical Monitoring and Computing·Hans-Joachim Priebe
Aug 3, 2020·BMC Anesthesiology·Hans-Joachim Priebe
Aug 17, 2020·BMC Anesthesiology·Marc LickerChristoph Ellenberger
Apr 29, 2019·Journal of Clinical Monitoring and Computing·Marc Licker, Christoph Ellenberger

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Methods Mentioned

BETA
coronary artery bypass

Clinical Trials Mentioned

NCT00788242

Software Mentioned

QLAB
STATA
CMQ
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