Prevaccination distribution of human papillomavirus types in women attending at cervical cancer screening in Belgium

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Marc ArbynChristophe Depuydt

Abstract

Before the introduction of vaccination against human papillomaviruses (HPV) as a new strategy of combating cervical cancer, it is required to describe the baseline prevalence of HPV infection as well as the distribution of the different HPV types in the population and among women with cervical lesions. Approximately 10,000 liquid cervical cell samples from women, resident of Flanders (North Belgium) and participating in cervical cancer screening, were assessed cytologically and virologically with a multiplex real-time PCR using primers targeting the E6/E7 genes of 16 HPV types. Correlations of HPV infection with age, geographic area, and occurrence of cytologic lesions were assessed. The prevalence of cytologic abnormalities was atypical squamous cells of undetermined significance (ASC-US), 1.6%; atypical glandular cells (AGC), 0.2%; low-grade squamous intraepithelial lesion (LSIL), 2.6%; atypical squamous cells, HSIL cannot be excluded (ASC-H), 0.3%; and high-grade squamous intraepithelial lesion (HSIL), 1.2%. The frequency of high-risk HPV infections was 11% in women without cytologic abnormalities, 77% in ASC-US, 32% in AGC, 85% in LSIL, and 93% in ASC-H and HSIL. The prevalence of high-risk HPV infection was highest in wome...Continue Reading

References

Nov 10, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M Arbyn, H Van Oyen
Jan 17, 2002·Journal of the National Cancer Institute·Mark E ShermanUNKNOWN Atypical Squamous Cells of Undetermined Significance/Low-Grade Squamous Intraepithelial Lesion Triage Study Group
Apr 23, 2002·JAMA : the Journal of the American Medical Association·Diane SolomonUNKNOWN Bethesda 2001 Workshop
Feb 7, 2003·The New England Journal of Medicine·Nubia MuñozUNKNOWN International Agency for Research on Cancer Multicenter Cervical Cancer Study Group
Apr 16, 2005·The Lancet Oncology·Vincent CoglianoUNKNOWN WHO International Agency for Research on Cancer
May 17, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Gary M CliffordJeanne M Pimenta
Jul 29, 2005·Cytopathology : Official Journal of the British Society for Clinical Cytology·E BeerensC A Cuvelier
Aug 27, 2005·Vaccine·Subhash C Arya
Aug 29, 2006·Gynecologic Oncology·Chris J MeijerPhilip E Castle
Sep 5, 2006·Vaccine·Margaret StanleyIan Frazer
Sep 5, 2006·Vaccine·Laura A Koutsky, Diane M Harper
Sep 23, 2006·International Journal of Cancer. Journal International Du Cancer·Silvia FranceschiNubia Muñoz
Dec 16, 2006·Cytopathology : Official Journal of the British Society for Clinical Cytology·C E DepuydtJ J Bogers
Jan 30, 2007·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Marc Arbyn, Joakim Dillner
Apr 4, 2007·International Journal of Cancer. Journal International Du Cancer·Jennifer S SmithGary M Clifford
Apr 18, 2007·Clinical and Experimental Immunology·J DillnerL Dillner
May 15, 2007·The New England Journal of Medicine·UNKNOWN FUTURE II Study Group
May 15, 2007·The New England Journal of Medicine·Suzanne M GarlandUNKNOWN Females United to Unilaterally Reduce Endo/Ectocervical Disease (FUTURE) I Investigators
Jun 19, 2007·Cytopathology : Official Journal of the British Society for Clinical Cytology·M ArbynP Martin-Hirsch
Jul 20, 2007·Cytopathology : Official Journal of the British Society for Clinical Cytology·A HerbertM Arbyn
Aug 21, 2007·JAMA : the Journal of the American Medical Association·Allan HildesheimUNKNOWN Costa Rican HPV Vaccine Trial Group
Sep 1, 2007·Journal of Cellular and Molecular Medicine·C E DepuydtJ J Bogers
Sep 11, 2007·Lancet·Mark SchiffmanSholom Wacholder
Sep 25, 2007·Lancet·Davide Mauri, Nikolaos P Polyzos
Jan 30, 2008·Journal of Clinical Pathology·G A V BouletJ J Bogers
Apr 9, 2008·British Journal of Cancer·A SargentUNKNOWN ARTISTIC Study Group
Jun 12, 2008·Journal of Cellular and Molecular Medicine·Christophe E DepuydtJohannes J Bogers
Jul 22, 2008·Vaccine·Diane M Harper, Jorma Paavonen

❮ Previous
Next ❯

Citations

Apr 9, 2010·Journal of Cancer Research and Clinical Oncology·Perle Ernoux-NeufcoeurSven Saussez
Nov 17, 2009·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Gaëlle A V BouletJohannes J Bogers
Feb 15, 2013·Journal of the International AIDS Society·Deborah KonopnickiNathan Clumeck
Jul 22, 2010·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Philippe SimonJean Christophe Noël
Aug 28, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Hugo De VuystSilvia Franceschi
May 27, 2014·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Mireille MerckxDavy Vanden Broeck
Nov 11, 2010·Clinical and Experimental Immunology·J DillnerL Dillner
Oct 5, 2012·International Journal of Cancer. Journal International Du Cancer·Markus SchmittUNKNOWN VALGENT Study Group
Sep 10, 2011·American Journal of Obstetrics and Gynecology·Ina H BenoyChristophe E Depuydt
Apr 16, 2011·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Anaëlle DuraySven Saussez
May 17, 2011·International Journal of STD & AIDS·E ShikovaP Kalascheva-Zaimova
Aug 16, 2014·The Journal of Pathology·Marc ArbynJoakim Dillner
Mar 11, 2020·European Journal of Public Health·Vincent De PrezPiet Bracke
Aug 30, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Sumalee SiriaunkgulSurapan Khunamornpong
Jul 1, 2016·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Sonia MenonDavy van den Broeck
Jul 21, 2020·The Journal of Obstetrics and Gynaecology Research·Rosario Lara-PeñarandaJuan Pedro Martínez-Cendán
Jun 25, 2016·International Journal of Cancer. Journal International Du Cancer·Christophe E DepuydtJohannes J Bogers
Jan 22, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Markus SchmittUNKNOWN VALGENT study group
Feb 8, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Christophe E DepuydtJohannes J Bogers

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.