Prevalence and Associated Features of Anxiety Disorder Comorbidity in Bipolar Disorder: A Meta-Analysis and Meta-Regression Study

Frontiers in Psychiatry
Hale Yapici EserDost Ongur

Abstract

Objective: Bipolar disorder is highly comorbid with anxiety disorders, however current and lifetime comorbidity patterns of each anxiety disorder and their associated features are not well studied. Here, we aimed to conduct a meta-analysis and meta-regression study of current evidence. Method: We searched PubMed to access relevant articles published until September 2015, using the keywords "Bipolar disorder" or "Affective Psychosis" or "manic depressive" separately with "generalized anxiety," "panic disorder," "social phobia," "obsessive compulsive," and "anxiety." Variables for associated features and prevalence of anxiety disorders were carefully extracted. Results: Lifetime any anxiety disorder comorbidity in BD was 40.5%; panic disorder (PD) 18.1%, generalized anxiety disorder (GAD) 13.3%, social anxiety disorder (SAD) 13.5% and obsessive compulsive disorder (OCD) 9.7%. Current any anxiety disorder comorbidity in BD is 38.2%; GAD is 15.2%, PD 13.3%, SAD 11.7%, and OCD 9.9%. When studies reporting data about comorbidities in BDI or BDII were analyzed separately, lifetime any anxiety disorder comorbidity in BDI and BDII were 38% and 34%, PD was 15% and 15%, GAD was 14% and 16.6%, SAD was 8% and 13%, OCD was 8% and 10%, respec...Continue Reading

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Citations

Jan 23, 2019·Bipolar Disorders·Awais Aftab, Martha Sajatovic
May 28, 2019·Psychiatry Investigation·Kiwon KimYong Chon Park
Jan 4, 2020·Acta Psychiatrica Scandinavica·H Yapıcı EserD Öngür
Jul 1, 2020·Frontiers in Psychiatry·Heinz Grunze, Christoph Born
Jan 12, 2019·World Journal of Psychiatry·Mamidipalli Sai SpoorthySandeep Grover
May 30, 2020·Psychiatry Research·Gabriele Di SalvoGianluca Rosso
Dec 7, 2020·Lancet·Roger S McIntyreRodrigo B Mansur
Apr 22, 2021·Psychological Medicine·Kevin S O'Connell, Brandon J Coombes
Jun 3, 2021·Medicina·Giulio Emilio BrancatiGiulio Perugi
Jun 7, 2021·Psychiatry Research·Leonid BravermanMichael Poyurovsky
Dec 11, 2019·Journal of Affective Disorders·Panagiotis FerentinosKonstantinos N Fountoulakis

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Software Mentioned

Comprehensive Meta - analysis
PRISMA
MOOSE

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