Abstract
The aim of this study was to investigate the prevalence and characteristics of resistant Klebsiella pneumoniae isolates in the pediatric setting in China. A total of 201 non-duplicate K. pneumoniae isolates were obtained from 432 pediatric inpatients suffering from respiratory tract infections. One hundred and thirty-eight K. pneumoniae isolates were determined to be extended-spectrum beta-lactamase-producers. Of all ESBL-producing isolates, 138 (100%) were resistant to piperacillin, ampicillin, cefazolin, and aztreonam, 136 (98.4%) to cefuroxime, 126 (91.2%) to ceftriaxone and co-trimoxazole, 120 (87.4%) to cefoperazone, 91 (65.8%) to ceftazidime, 78 (56.5%) to gentamicin, and 72 (52.4%) to cefepime. TEM was the main type of beta-lactamase among ESBL-producing K. pneumoniae, followed by SHV and CTX-M-1. Of the 30 isolates harboring CTX-M-producers, 53.3% co-produced TEM, 36.7% co-produced SHV, and the remaining isolates co-produced SHV and TEM. The data show that there is a high prevalence of ESBL-producing K. pneumoniae infections among pediatric inpatients in the region.
References
Jun 1, 1988·Journal of Clinical Microbiology·K TullusL G Burman
Oct 10, 1998·Clinical Microbiology Reviews·R Podschun, U Ullmann
May 19, 2000·Antimicrobial Agents and Chemotherapy·J J YanI J Su
Feb 13, 2001·The Journal of Hospital Infection·C PeñaF Gudiol
Mar 27, 2001·The Journal of Antimicrobial Chemotherapy·J E CorkillC A Hart
Oct 5, 2001·Clinical Microbiology Reviews·P A Bradford
Sep 14, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John M QualeAdedeyo Adedeji
Aug 3, 2004·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Caio MendesPhilip Turner
Jan 10, 2009·The Pediatric Infectious Disease Journal·Durrane ThaverAnita K M Zaidi
Apr 7, 2009·International Journal of Antimicrobial Agents·Stefan Panaiotov
May 22, 2009·Journal of Clinical Microbiology·Jan M BellRonald N Jones
May 12, 2010·Antimicrobial Agents and Chemotherapy·Daryl J HobanJoseph DiPersio
Mar 9, 2011·The Journal of Infection·Yen-Hsu ChenDavid L Paterson
Mar 1, 2012·Scandinavian Journal of Infectious Diseases·Dennis Schrøder HansenUNKNOWN DANRES Study Group
Citations
Apr 14, 2015·Infectious Diseases·Lea PapstMateja Pirš
Jan 28, 2015·Clinical Cancer Investigation Journal·Dalin WangKun Chen
Feb 7, 2015·Foodborne Pathogens and Disease·Haiyun WuBaowei Yang
Feb 28, 2019·Frontiers in Microbiology·Xiaohui ChiLennart E Nilsson