Prevalence and circadian variations of ST-segment depression and its concomitant blood pressure changes in asymptomatic systemic hypertension

The American Journal of Cardiology
R AsmarM Safar

Abstract

Coronary artery disease is a major complication of hypertension; one of its manifestations is silent ischemia. The aim of this study was to assess the prevalence and circadian distribution of ST-segment depression together with concomitant blood pressure (BP) and heart rate variations. One hundred patients (male:female ratio 1:1) with a mean age (+/- SD) of 51 +/- 8 years underwent ambulatory monitoring using the combined AMP 5600 monitor which simultaneously records a continuous Holter electrocardiogram and intermittent noninvasive BP measurements at 15-minute intervals, with extra measurements triggered by detection of a horizontal or downsloping ST depression (> 1 mm and >60 seconds). Cardiovascular risk factors were fully evaluated in all patients; accurate and reliable echocardiogram enabled left ventricular mass index to be calculated in 52 patients. Twenty-three patients (15 men and 8 women) experienced a total of 72 episodes of ST depression. Duration of such episodes (mean +/- SD) was 132 +/- 65 seconds and amplitude was 1.51 +/- 0.55 mm. Circadian distribution showed 2 peaks: on awakening and in the late afternoon periods. The mean ambulatory BP load was greater in the patients with than without ST-segment depression ...Continue Reading

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Citations

Apr 14, 2000·Clinical Cardiology·A Unzueta-MontoyaH Hernández-y Hernández
Nov 27, 2009·Archives of Gerontology and Geriatrics·Sara MutikainenUrho M Kujala
Jun 15, 2007·International Journal of Cardiology·Theodoros XanthosLila Papadimitriou
May 19, 2004·Headache·Arthur H ElkindCharlotte Keywood
May 7, 2010·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Doina GherghelRebekka Heitmar
Aug 28, 2016·Internal and Emergency Medicine·Domenico RendinaFerruccio Galletti
Nov 21, 2008·Blood Pressure Monitoring·Nikolaos A ZakopoulosSpyridon D Moulopoulos
Nov 1, 2001·Journal of Human Hypertension·E O'BrienUNKNOWN Anglo-Scandinavian Cardiac Outcomes Trial
Nov 1, 2000·Journal of Hypertension·D BoonG A van Montfrans

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