PMID: 20635579Jul 20, 2010Paper

Prevalence and clinical outcome of spontaneous bacterial peritonitis in hospitalized patients with liver cirrhosis: a prospective observational study in central part of Croatia

Acta clinica Croatica
Ivan Gunjaca, Ivan Francetić

Abstract

Spontaneous bacterial peritonitis (SBP) is a serious complication of liver cirrhosis and is defined as infected ascites in the absence of any recognizable secondary cause of infection. The aim of the study was to evaluate the prevalence, incidence, pathogens and clinical outcome of SBP. This prospective observational study included 108 cirrhotic patients with ascites treated during 18 months. Patients were divided into two groups according to diagnostic criteria of SBP: SBP group (n=23) and non-SBP group (n=85). Differences in clinical outcomes between the two groups were analyzed, including mortality rate, incidence of gastrointestinal bleeding, bacteremia/sepsis and frequency of rehospitalization. The pathogens responsible for SBP were analyzed in SBP group. The prevalence of SBP was 21% and incidence 14.1% per year. Statistically significant between-group differences were recorded in mortality (26% vs. 4.7%; P=0.017), incidence of gastrointestinal bleeding (39% vs. 11.7%; P=0.015) and rehospitalization frequency (47.8% vs. 20%; P=0.05). The incidence of sepsis following episode of gastrointestinal bleeding was similar in both groups (55.5% vs. 50%; P=0.892). The following pathogens were responsible for SBP: Escherichia coli ...Continue Reading

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