Prevalence and clinical significance of a patent foramen ovale in patients with chronic obstructive pulmonary disease

Respiratory Medicine
Suleyman Savas HacievliyagilTalat Kilic

Abstract

A patent foramen ovale (PFO) is not widely recognized as a factor contributing to hypoxemia in patients with chronic obstructive pulmonary disease (COPD). We therefore sought to clarify the prevalence and clinical significance of a PFO in patients with COPD, and to analyze the factors related to its occurrence. This study included 52 consecutive stable patients with COPD and 50 healthy controls. The demographic and clinical features of the study group were noted. To test for a PFO, standard and contrast transthoracic echocardiographic examinations were performed while resting and during the Valsalva maneuver (VM). Patients performed 6-min walking tests (6 MWT), and the distances traveled were measured. During VM, we detected a PFO in 23 COPD patients and 10 healthy controls (P<0.01). A PFO was detected while resting in 11 COPD patients, but in none of the controls (P=0.001). Comparison of multiple parameters between COPD patients with and without a PFO during VM did not reveal any clinically significant differences. When we compared COPD patients with and without a PFO during resting, however, we found that the former had longer durations of disease, lower PaO2 and SaO2, higher dyspnea scores, shorter distances walked during 6 ...Continue Reading

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Related Concepts

Radiographic contrast media
Cardiopulmonary Exercise Test
Forced Expiratory Volume Function
Persistent Ostium Primum
Oximetry, Pulse
Valsalva Maneuver
Echocardiography, Transesophageal
Chronic Airflow Obstruction

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