Prevalence and clinical significance of neutropenia discovered in routine complete blood cell counts: a longitudinal study

Journal of Internal Medicine
Christen Lykkegaard AndersenJan Palmblad

Abstract

Neutropenia, defined as an absolute blood neutrophil count (ANC) <1.5 G L(-1) , may accompany a variety of diseases. However, the clinical significance of neutropenia detected in a routine complete blood cell count is poorly understood. Using a primary care resource, comprising more than 370 000 individuals, we assessed the association with a number of previously recognized conditions as well as all-cause mortality in the 4 years following the identification of neutropenia. By matching laboratory data with Danish nationwide health registers, risk estimates were assessed. Neutropenia was observed in approximately 1% of all individuals and was associated dose dependently with viral infections, haematological malignancies (but not autoimmune disorders or solid cancers) and mortality. Neutropenia was particularly associated with HIV, acute leukaemias and myelodysplastic syndromes. Odds ratios [95% confidence interval (CI)] for viral infections were 2.32 (1.84-2.91), 2.80 (2.20-3.57) and 4.77 (3.22-7.07) for subnormal (≥1.5-1.8 G L(-1) ), mild (≥1.0-1.5 G L(-1) ) and moderate-severe (≥0.0-1.0 G L(-1) ) neutropenic individuals, respectively (all P < 0.001). Likewise, odds ratios (95% CI) for haematological malignancies were 3.23 (2.3...Continue Reading

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Citations

Jan 19, 2016·Expert Review of Hematology·Jan PalmbladHelen A Papadaki
Jul 13, 2016·Drugs & Aging·Su-Ann YeohRichard Hull
Nov 20, 2016·Journal of Gastroenterology and Hepatology·Berrie MeijerNanne K H de Boer
Aug 16, 2019·The Journal of Infectious Diseases·Delal AkdagSusanne Dam Nielsen
Oct 17, 2019·International Journal of Molecular Sciences·Fien H. R. De WinterSamir Kumar-Singh
Apr 16, 2020·MMW Fortschritte der Medizin·Frank Ziemann, Klaus Metzeler
Nov 15, 2016·Current Opinion in Hematology·David C Dale, Audrey A Bolyard

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