Prevalence and Clonal Distribution of Azole-Resistant Candida parapsilosis Isolates Causing Bloodstream Infections in a Large Italian Hospital.

Frontiers in Cellular and Infection Microbiology
Cecilia MartiniMaurizio Sanguinetti

Abstract

The most prevalent cause of nosocomial bloodstream infection (BSI) among non-C. albicans Candida species, Candida parapsilosis, may not only be resistant to azole antifungal agents but also disseminate to vulnerable patients. In this survey of BSIs occurring at a large Italian hospital between May 2014 and May 2019, C. parapsilosis accounted for 28.5% (241/844) of all Candida isolates causing BSI episodes. The majority of episodes (151/844) occurred in medical wards. Across the 5 yearly periods, the rates of azole non-susceptibility were 11.8% (4/34), 17.8% (8/45), 28.6% (12/42), 32.8% (19/58), and 17.7% (11/62), respectively, using the Sensititre YeastOne® method. Among azole non-susceptible isolates (54/241; 22.4%), 49 were available for further investigation. Using the CLSI reference method, all 49 isolates were resistant to fluconazole and, except one (susceptible dose-dependent), to voriconazole. Forty (81.6%) isolates harbored the Erg11p Y132F substitution and nine (18.4%) isolates the Y132F in combination with the Erg11p R398I substitution. According to their genotypes, as defined using a microsatellite analysis based on six short tandem repeat markers, 87.7% of isolates (43/49) grouped in two major clusters (II and III)...Continue Reading

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Citations

Jan 16, 2021·Journal de mycologie médicale·Eliane Martins da SilvaTerezinha I E Svidzinski
May 11, 2021·Frontiers in Cellular and Infection Microbiology·Amir ArastehfarCornelia Lass-Flörl
Jan 28, 2022·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Murat KutluÇağrı Ergin

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Methods Mentioned

BETA
PCR
PCRs
genotyping

Software Mentioned

GeneMapper Software
Chromas
MEGA
Applied BioNumerics
GraphPad Prism

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