Prevalence and cognitive impact of medial temporal atrophy in a hospital stroke service: retrospective cohort study

International Journal of Stroke : Official Journal of the International Stroke Society
Valeria KebetsDavid J Werring


Cerebrovascular disease and neurodegeneration cause cognitive impairment and frequently coexist. Our objectives were to investigate the prevalence and cognitive impact of medial temporal lobe atrophy - a radiological marker often associated with Alzheimer's disease - in a hospital stroke service. Retrospective cohort study of patients from a hospital stroke service. Patients assessed for suspected ischemic stroke or transient ischemic attack, irrespective of final diagnosis, underwent neuropsychological testing and magnetic resonance imaging. medial temporal lobe atrophy, white matter hyperintensities, lacunes, and cerebral microbleeds were rated using established criteria and validated scales. The associations between medial temporal lobe atrophy and cognition were tested using multivariable logistic regression analyses, adjusted for age and imaging markers of cerebrovascular disease. Three hundred and ninety-three patients were included, of whom 169 (43%; 95% confidence interval: 38·1-48·1%) had medial temporal lobe atrophy; in 38 patients (9·7%), medial temporal lobe atrophy was severe (mean score ≥2). In unadjusted logistic regression analyses in the whole cohort, mean medial temporal lobe atrophy score was associated with ...Continue Reading


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Related Concepts

Ischemic Cerebrovascular Accident
Biological Markers
Ischemic Attack
Magnetic Resonance Imaging
Blood Vessel
Malignant Neoplasm of Temporal Lobe
Memory for Designs Test
Nerve Degeneration

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