Prevalence and correlates of high red blood cell folate concentrations in the Canadian population using 3 proposed cut-offs

Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme
Cynthia K ColapintoMark S Tremblay

Abstract

A distinct shift towards higher folate concentrations has emerged in Canada. These higher concentrations have known benefits, including prevention of neural tube defects, but concerns have been raised regarding potential associations with adverse health outcomes. The aim of this research was to propose cut-offs for high red blood cell (RBC) folate concentrations and identify their correlates. RBC folate was measured in a nationally representative cross-sectional sample of Canadians (N = 5248) aged 6 to 79 years. RBC folate concentrations were adjusted from the IMMULITE 2000 immunoassay to a microbiologic assay. The population was characterized at 3 RBC folate cut-offs: 1450 nmol/L, 1800 nmol/L, and 2150 nmol/L. We used t tests to examine differences by age, sex, income, and body mass index (BMI) at each cut-off and logistic regression to explore associations with folic acid supplement intake. The prevalence of high RBC folate was 16%, 6%, and 2% at thresholds of 1450 nmol/L, 1800 nmol/L, and 2150 nmol/L, respectively. Females, those aged 60 to 79 years, and overweight or obese participants had the greatest prevalence of having high RBC folate at each cut-off. Folic acid supplement users were more likely than non-users to have h...Continue Reading

References

Dec 6, 1995·JAMA : the Journal of the American Medical Association·L E DalyJ M Scott
Jan 21, 2006·The Journal of Nutrition·Stanley Zlotkin
Dec 7, 2007·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·R Douglas WilsonUNKNOWN MOTHERISK
Feb 9, 2008·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Y I Goh, G Koren
Jul 26, 2008·Birth Defects Research. Part A, Clinical and Molecular Teratology·Philippe De WalsTheophile Niyonsenga
Jan 1, 2009·The American Journal of Clinical Nutrition·Lindsay H Allen
Oct 30, 2009·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·J FifeF A Frizelle
Aug 27, 2010·The American Journal of Clinical Nutrition·Yaseer A ShakurDeborah L O'Connor
Oct 12, 2010·The Cochrane Database of Systematic Reviews·Luz Maria De-RegilJuan Pablo Peña-Rosas
Dec 15, 2010·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Cynthia K ColapintoMark S Tremblay
May 27, 2011·The Journal of Nutrition·Christine M PfeifferClifford L Johnson
Apr 1, 2010·Canadian Journal of Dietetic Practice and Research : a Publication of Dietitians of Canada = Revue Canadienne De La Pratique Et De La Recherche En Diététique : Une Publication Des Diététistes Du Canada·UNKNOWN Dietitians of CanadaDonna Secker
Sep 9, 2011·The American Journal of Clinical Nutrition·Amanda J MacFarlaneYipu Shi
Oct 25, 2011·Cancer Epidemiology·Joseph E BaggottTsunenobu Tamura
Jan 14, 2012·BMJ Open·Tale Norbye WienMarianne Klemp
Jul 31, 2014·BMJ : British Medical Journal·Krista S CriderRobert J Berry

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Citations

Sep 10, 2016·The British Journal of Nutrition·Adriana N MudryjNancy Yu
Jun 8, 2017·Nutrition Research Reviews·Silvia MaffoniHellas Cena
Mar 18, 2016·Canadian Journal of Public Health = Revue Canadienne De Santé Publique·Mahvash ShereGideon Koren

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