Prevalence and correlates of multiple organ damage in a never-treated hypertensive population: role of ambulatory blood pressure

Blood Pressure Monitoring
Cesare CuspidiGiuseppe Mancia

Abstract

Available evidence on multiple target organ damage (TOD) in the early phases of essential hypertension is scanty. We examined the prevalence and correlates of multiple TOD in never-treated patients with recently diagnosed hypertension. A total of 602 consecutive outpatients with grades 1 and 2 hypertension underwent the following procedures: (i) routine examination, (ii) 24-h urine collection for microalbuminuria, (iii) ambulatory blood pressure monitoring over two 24-h periods within 4 weeks, (iv) echocardiography, (v) carotid ultrasonography. TOD at cardiac, vascular and renal levels was defined according to major international hypertension guidelines. Prevalence rates of patients negative for TOD (group I) or positive for one (group II), two (group III), or three (group IV) markers of TOD were as follows: 45, 33, 17 and 5%. In group II, alterations in left ventricular structure and geometry were more frequently present than carotid atherosclerosis and microalbuminuria; a similar trend was found in group III where a close association between cardiac and vascular, but not renal, signs of TOD was observed. In multiple regression analyses the risk of having three TOD was significantly related to age [odds ratio (OR): 2.11, 95% c...Continue Reading

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Citations

Sep 30, 2008·Blood Pressure·Cesare CuspidiGiuseppe Mancia
Apr 11, 2012·Blood Pressure·Gabriel Coll-De-TueroJesús Gelado-Ferrero
Feb 14, 2019·Cardiovascular Diabetology·Andrea Maria MarescaColomba Falcone
Aug 31, 2018·European Heart Journal·Bryan WilliamsUNKNOWN ESC Scientific Document Group
Mar 19, 2021·British Journal of Clinical Pharmacology·Paul G HunterNeeraj Dhaun

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