Abstract
There is a need to assess promising biomarkers for diagnosis and treatment response in real-life settings. Despite the important role of vascular risk factors, cardiovascular biomarkers have played a minor role in dementia research. Agonistic autoantibodies (agAAB) directed against G-protein-coupled receptors (GPCR) are discussed as modulators of pathology and clinical manifestation. 1) Describe prevalence of agAAB directed against GPCR, especially agABB against α1-adrenergic receptors (α1-AR-agAAB) and agABB directed against β2-adrenergic receptors (β2-AR-agAAB) and 2) identify factors associated with agAAB in people with dementia during routine care. Blood samples and data from 95 subjects who screened positive for dementia from a primary care cohort, analyzed using an enzyme-linked immunosorbent assay (ELISA) for detecting agAAB. Sociodemographic and clinical data were assessed, and medical records checked. In 40 (42%) samples, agAAB was detected, with n = 29 (31%) representing α1-AR-agAAB and n = 21 (22%) β2-AR-agAAB. There was no association between the presence of any antibody and a formal diagnosis of dementia. However, patients with coronary heart disease were more likely (OR = 4.23) to have α1-AR-agAAB than those witho...Continue Reading
References
Jun 8, 2001·Zeitschrift für Gerontologie und Geriatrie·H Bickel
Apr 6, 2002·Stroke; a Journal of Cerebral Circulation·J C de la Torre
Nov 23, 2006·Nature Medicine·Yanxiang NiGang Pei
Nov 18, 2008·PloS One·Katrin WenzelPeter Karczewski
Jan 21, 2012·Scandinavian Journal of Immunology·P KarczewskiM Bimmler
Jan 28, 2012·Journal of Public Health Policy·James ChauvinPamela Fuselli
May 12, 2012·Trials·Jochen René ThyrianWolfgang Hoffmann
Aug 4, 2012·PloS One·Peter KarczewskiMarion Bimmler
Jan 12, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Martin PrinceCleusa P Ferri
Jan 30, 2013·Atherosclerosis. Supplements·Michael DandelRoland Hetzer
Feb 28, 2013·Central European Journal of Public Health·Jochen René Thyrian, Wolfgang Hoffmann
Jan 15, 2014·Biochemical Pharmacology·Bushra ImtiazHilkka Soininen
Jun 6, 2014·Journal of Alzheimer's Disease : JAD·Tilly EichlerWolfgang Hoffmann
Nov 12, 2014·BMC Medicine·Johannes Attems, Kurt A Jellinger
Sep 1, 2015·Lancet Neurology·Stefan TeipelAndreas Fellgiebel
Apr 1, 2016·Journal of Alzheimer's Disease : JAD·Jochen René ThyrianWolfgang Hoffmann
Oct 19, 2016·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Petra HempelMarion Bimmler
Mar 1, 2015·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Tilly EichlerWolfgang Hoffmann
Aug 5, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·UNKNOWN METACOHORTS Consortium. Electronic address: joanna.wardlaw@ed.ac.uk, UNKNOWN METACOHORTS Consortium
Nov 12, 2016·Journal of Alzheimer's Disease : JAD·Stefan J TeipelIngo Kilimann
Apr 14, 2017·Zeitschrift für Gerontologie und Geriatrie·Ingo KilimannStefan J Teipel
Jul 27, 2017·JAMA Psychiatry·Jochen René ThyrianWolfgang Hoffmann
Citations
Sep 25, 2019·Journal of the American Heart Association·Amanda J Miller, Taylor A Doherty
Jun 25, 2020·Journal of Clinical Medicine·Sylvia StrackeMarcus Dörr
Oct 30, 2020·Frontiers in Pharmacology·Dianne M Perez
Jun 12, 2021·Frontiers in Cell and Developmental Biology·Dianne M Perez