Prevalence and determinants of anemia in adults with complex congenital heart disease and ventricular dysfunction (subaortic right ventricle and single ventricle physiology)

The American Journal of Cardiology
Nicholas CollinsCandice K Silversides

Abstract

Anemia is well recognized as a marker of poor prognosis in patients with acquired heart disease and heart failure. Adults with complex congenital heart disease and ventricular dysfunction (subaortic right ventricle or single-ventricle physiology) represent a different population, because they are typically much younger and have less co-morbidity compared with patients with acquired forms of heart disease. The purpose of this study was to evaluate the prevalence and determinants of anemia in this population. Baseline hemoglobin levels were recorded at the time of the initial clinic visit, and final hemoglobin levels were those recorded before death or transplantation or at study completion. Anemia was defined as hemoglobin <135 g/L in men and <120 g/L in women. One hundred sixty-seven patients (100 men, mean age 34 +/- 8 years, mean ejection fraction 35 +/- 9%) were included, 66 with atrial switch operations, 42 with congenitally corrected transposition of the great arteries, and 59 with Fontan physiology. The mean hemoglobin level at baseline was 149 +/- 22 g/L and at follow-up was 139 +/- 29 g/L. The overall prevalence of anemia was 29% at completion. Hyponatremia, decreased renal function, and the use of warfarin were indepen...Continue Reading

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Citations

Apr 12, 2011·Journal of Cardiothoracic and Vascular Anesthesia·Susan S Eagle, Suanne M Daves
Apr 5, 2014·Journal of cardiology·Lidia Tomkiewicz-PajakPiotr Podolec
Mar 12, 2011·Congenital Heart Disease·Anji T Yetman, Melanie D Everitt
Nov 21, 2009·Journal of the American College of Cardiology·Konstantinos DimopoulosMichael A Gatzoulis
May 29, 2016·Trends in Cardiovascular Medicine·Stephen A GaetaRichard A Krasuski
Oct 11, 2017·Circulation·George K LuiUNKNOWN American Heart Association Adult Congenital Heart Disease Committee of the Council on Clinical Cardiology and Council on Car
Sep 11, 2019·International Anesthesiology Clinics·Genevieve E StaudtSusan S Eagle
Mar 11, 2017·Cardiology in the Young·Bradley S MarinoAlvin J Chin
Feb 13, 2019·Cardiovascular & Hematological Disorders Drug Targets·Miriam MichelHideo Ohuchi
Oct 5, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Andrew L ChengJohn C Wood

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