Prevalence and determinants of vitamin D deficiency in the third trimester of pregnancy: a multicentre study in Switzerland

The British Journal of Nutrition
Jean-Philippe KriegerKatharina Quack Lötscher

Abstract

Vitamin D deficiency during pregnancy is associated with negative health consequences for mothers and their infants. Data on the vitamin D status of pregnant women in Switzerland are scarce. A three-centre study was conducted in the obstetric departments of Zurich, Bellinzona and Samedan (Switzerland) to investigate the prevalence and determinants of vitamin D deficiency (serum 25-hydroxyvitamin D (25(OH)D)<50 nmol/l) in 3rd-trimester pregnant women living in Switzerland (n 305), and the correlation between 25(OH)D in pregnant women and their offspring at birth (n 278). Demographic and questionnaire data were used to explore the determinants of vitamin D deficiency. Median concentration of serum 25(OH)D in the third trimester of pregnancy was 46·0 nmol/l (1st-3rd quartiles: 30·5-68·5), representing a 53·4 % prevalence of vitamin D deficiency. 25(OH)D levels in the umbilcal cord blood (median: 50·0 nmol/l; 1st-3rd quartiles: 31·0-76·6) strongly correlated with mothers' serum 25(OH)D (Spearman's correlation ρ=0·79, P<0·001). Multivariable logistic regression analysis showed that significant determinants of vitamin D deficiency in pregnant women were centre of study, country of origin, season of delivery and vitamin D supplement i...Continue Reading

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Citations

Dec 25, 2019·The Journal of Clinical Endocrinology and Metabolism·Mengdi LuAugusto A Litonjua
Oct 17, 2018·International Journal of Environmental Research and Public Health·Stefan PilzWinfried März
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Jan 29, 2021·Nutrients·Ola HysajSabine Rohrmann
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Dec 12, 2021·Archives of public health = Archives belges de santé publique·Farideh AghaeiSaeideh Ghaffarifar

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