PMID: 9423882Jan 10, 1998Paper

Prevalence and distribution of the hmw and hia genes and the HMW and Hia adhesins among genetically diverse strains of nontypeable Haemophilus influenzae

Infection and Immunity
Joseph W St GemeS J Barenkamp

Abstract

Nontypeable Haemophilus influenzae is a common cause of human disease and initiates infection by colonizing the upper respiratory tract. In previous work we identified high-molecular-weight adhesins referred to as HMW1 and HMW2, expressed by nontypeable strain 12, and determined that most strains of nontypeable H. influenzae express one or two antigenically related proteins. More recently, we determined that some strains lack HMW1- and HMW2-like proteins and instead express an adhesin called Hia. In the present study, we determined the prevalence and distribution of the hmw and hia genes in a collection of 59 nontypeable strains previously characterized in terms of genetic relatedness. Based on Southern analysis, 47 strains contained sequences homologous to the hmw1 and hmw2 genes and nine strains contained homologs to hia. No strain harbored both hmw and hia, and three strains harbored neither. Although the hmw and hia genes failed to define distinct genetic divisions, the hmw-deficient strains formed small clusters or lineages within the larger population structure. Additional analysis established that the IS1016 insertion element was uniformly absent from strains containing hmw sequences but was present in two-thirds of the ...Continue Reading

References

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Citations

Jan 17, 2004·The Journal of Biological Chemistry·Neeraj K SuranaJoseph W St Geme
Jun 22, 2005·Journal of Bacteriology·Shane E CotterJoseph W St Geme
Jun 29, 2006·Molecular Microbiology·Maria ScarselliBeatrice Aricò
Dec 11, 2007·Journal of Bacteriology·Alice L ErwinArnold L Smith
Apr 21, 2012·Journal of Medical Microbiology·Vanessa S TerraBrendan W Wren
Dec 18, 2012·Journal of Medical Microbiology·Michael E WatsonArnold L Smith
Apr 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·Matteo De ChiaraClaudio Donati
Aug 11, 2016·FEBS Letters·Benjamin Luke DuellKristian Riesbeck
Aug 14, 2020·International Journal of Molecular Sciences·Christian WegeleJulia Borkowski
Mar 26, 2003·Infection and Immunity·Carina A RodriguezElisabeth E Adderson
Jul 16, 2008·The Journal of Biological Chemistry·Julia GrossJoseph W St Geme
Jun 29, 2011·Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases·Keisuke SunakawaSatoshi Iwata
Jul 19, 2000·Infection and Immunity·M van SchilfgaardeJ Dankert
Jun 15, 2006·Molecular Microbiology·Amy Z BuscherJoseph W St Geme
Dec 6, 2008·The Pediatric Infectious Disease Journal·Timothy F MurphyStephen I Pelton
Mar 18, 2010·Molecular Microbiology·Gail G HardyYves V Brun
Dec 4, 2019·Medical Microbiology and Immunology·Arno ThibauVolkhard A J Kempf
May 23, 2000·The Pediatric Infectious Disease Journal·T F Murphy

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