Prevalence and diversity of small mammal-associated Bartonella species in rural and urban Kenya

PLoS Neglected Tropical Diseases
Jo E B HallidayMichael Y Kosoy

Abstract

Several rodent-associated Bartonella species are human pathogens but little is known about their epidemiology. We trapped rodents and shrews around human habitations at two sites in Kenya (rural Asembo and urban Kibera) to determine the prevalence of Bartonella infection. Bartonella were detected by culture in five of seven host species. In Kibera, 60% of Rattus rattus were positive, as compared to 13% in Asembo. Bartonella were also detected in C. olivieri (7%), Lemniscomys striatus (50%), Mastomys natalensis (43%) and R. norvegicus (50%). Partial sequencing of the citrate synthase (gltA) gene of isolates showed that Kibera strains were similar to reference isolates from Rattus trapped in Asia, America, and Europe, but that most strains from Asembo were less similar. Host species and trapping location were associated with differences in infection status but there was no evidence of associations between host age or sex and infection status. Acute febrile illness occurs at high incidence in both Asembo and Kibera but the etiology of many of these illnesses is unknown. Bartonella similar to known human pathogens were detected in small mammals at both sites and investigation of the ecological determinants of host infection status ...Continue Reading

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Citations

May 11, 2016·The American Journal of Tropical Medicine and Hygiene·Lile MalaniaMichael Kosoy
Jun 21, 2017·EcoHealth·Jamie L RothenburgerClaire M Jardine
Nov 1, 2016·Applied and Environmental Microbiology·Luiz Ricardo GonçalvesMarcos Rogério André
Sep 7, 2017·Pathogens and Global Health·Rory GibbKate E Jones
Dec 21, 2018·Vector Borne and Zoonotic Diseases·Luiza HatyokaArmanda Bastos
Aug 10, 2019·PeerJ·Lucila Moreno SalasDaniel González-Acuña
Apr 24, 2019·Tropical Medicine and Infectious Disease·Mercedes A Cheslock, Monica E Embers
Apr 25, 2020·BMC Public Health·Peninah M MunyuaMarc-Alain Widdowson
Jan 23, 2021·Vector Borne and Zoonotic Diseases·Elkanah OtiangAllen L Richards
Nov 19, 2020·Journal of Vector Ecology : Journal of the Society for Vector Ecology·Estefanía Abreu-YanesPilar Foronda
Aug 3, 2021·New Microbes and New Infections·T AzimiS Rafiei Tabatabaei

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Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

R
MegAlign
Lasergene
Clustal V
Lasergene 12 Core Suite

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