Sep 1, 1990

Prevalence and etiology of respiratory distress in infants of diabetic mothers: predictive value of fetal lung maturation tests

American Journal of Obstetrics and Gynecology
S L KjosM Stabler


The purpose of this study was to investigate the prevalence of respiratory distress syndrome attributable to surfactant deficiency in infants of diabetic mothers tested for fetal lung maturation. Three tests were assessed: (1) lecithin/sphingomyelin ratio, (2) phosphatidylglycerol concentration, and (3) optical density at 650 nm. From January 1987 through June 1989, 526 diabetic gestations were delivered within 5 days of fetal lung maturation testing. Surfactant-deficient respiratory distress syndrome was present in five infants (0.95%); all were less than 34 weeks' gestational age. Other causes of respiratory distress were transient tachypnea of the newborn (n = 5), hypertrophic cardiomyopathy (n = 4), pneumonia (n = 2), polycythemia (n = 1), and meconium aspiration syndrome (n = 1). The use of standard maturity values of lecithin/sphingomyelin ratio greater than or equal to 2.0, phosphatidylglycerol greater than 2% to 5%, and optical density at 650 nm greater than or equal to 0.150 were evaluated. Each test had a 100% sensitivity in identifying surfactant-deficient respiratory distress syndrome and a 100% negative predictive value in identifying the absence of disease. All three tests had a low positive predictive value: 15% ...Continue Reading

  • References2
  • Citations24


  • References2
  • Citations24


Mentioned in this Paper

Fetal Organ Maturity
Phosphatidyl glycerol
Fetal Lung
Surfactant [EPC]
Cardiac Hypertrophy
Endogenous Surfactants
Congenital Deficiency of Pulmonary Surfactant Protein B
Pregnancy in Diabetics

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