Prevalence and geographical variation of Factor V Leiden in patients with cerebral venous thrombosis: A meta-analysis

PloS One
Xinyuan LiShaokuan Fang

Abstract

Previous results regarding the prevalence of Factor V Leiden (FVL) in patients with cerebral venous thrombosis (CVT) varied remarkably. Therefore, we performed a meta-analysis to evaluate the potential association between FVL and CVT. The PubMed, Embase, Cochrane Central Register of Controlled Trials, and Web of Science were searched for relevant case-control studies. The data were pooled for analysis of the association between FVL and CVT with a random-effects model. Subgroup and sensitivity analyses were performed to evaluate the robustness of the results. Publication bias was assessed by funnel plot and the Egger's test. A total of 39 case-control studies including 1807 cases of CVT and 7699 control cases were included. FVL was more common in patients with CVT (195/1822) than in controls(369/7795), [odds ratio(OR) = 2.70, 95% confidence interval(CI) 2.16-3.38, P < 0.00001]. Results of subgroup analyses indicated that the association between FVL and CVT varied according to geographic regions. The associations between FVL and CVT were significant in studies from Germany (OR = 2.42, 95%CI 1.70-3.45, P < 0.00001), Brazil(OR = 2.82, 95%CI 1.24-6.42, P = 0.01), France (OR = 5.44, 95%CI 1.35-21.92, P = 0.02), Iran (OR = 6.61, 95%CI...Continue Reading

References

Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Jun 12, 2004·Stroke; a Journal of Cerebral Circulation·Carlos CantuFernando Barinagarrementeria
Mar 1, 2005·Thrombosis Research·Antonella TufanoAnna Maria Cerbone
Sep 22, 2005·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Véronique Le Cam-DuchezJeanne-Yvonne Borg
Jan 24, 2007·Lancet Neurology·Marie-Germaine Bousser, José M Ferro
Apr 3, 2007·Journal of Thrombosis and Thrombolysis·Adriano de Paula SabinoAna Paula Fernandes
Jun 13, 2009·Thrombosis Research·Richard H White, Craig R Keenan
Jul 23, 2009·BMJ : British Medical Journal·David MoherUNKNOWN PRISMA Group
May 21, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·I MartinelliP M Mannucci
Jun 16, 2010·Circulation·Ida MartinelliPier Mannuccio Mannucci
Feb 26, 2011·Stroke; a Journal of Cerebral Circulation·Thomas MarjotPankaj Sharma
Jul 30, 2011·Journal of Thrombosis and Haemostasis : JTH·N A Zakai, L A McClure
Oct 17, 2013·Seminars in Thrombosis and Hemostasis·Mandy N LauwSaskia Middeldorp
Sep 2, 2016·International Heart Journal·Göksel ÇinierŞahin Avsar
Sep 18, 2016·Advances in Experimental Medicine and Biology·Cristina Hotoleanu
Oct 21, 2016·Seminars in Thrombosis and Hemostasis·Marta Crous-BouChristopher Kabrhel
Jul 28, 2017·Stroke; a Journal of Cerebral Circulation·Eva A MistryMatthew R Fusco

❮ Previous
Next ❯

Citations

Mar 19, 2019·International Journal of Immunogenetics·Arezou SayadSoudeh Ghafouri-Fard
Jan 30, 2021·Journal of Translational Internal Medicine·Eray Yıldız, Funda Müşerref Türkmen

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging techniques

Software Mentioned

Stata
Review Manager

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.