Abstract
Subclinical acute rejection (SAR) occurs in about 30% of stable renal transplant patients and may be a risk factor for a poor allograft outcome. In the present study, the prevalence and clinical features of subclinical rejection, and the expression of immune activation markers in surveillance graft biopsies were assessed and correlated with late graft outcomes. Protocol biopsies were obtained at 2 and 12 months post-transplant in 32 and 26 patients, respectively, with stable renal function. The Banff 1997 criteria were used for histological diagnosis. Graft function and survival and proteinuria were assessed during the 36 months of follow-up. Immunohistochemical evaluation of cell subpopulations and immunoactivation markers were performed on protocol biopsies. The prevalence of SAR at 2 months and of chronic allograft nephropathy (CAN) at 12 months in representative biopsies was 55 and 50%, respectively. Patients with SAR presented mononuclear cell infiltration with an increased expression of CD3, CD4, CD68, IL-2R and granzyme B. Kidney graft function was significantly worse in patients with SAR at 2 months who had chronic rejection on biopsy at 12 months, but SAR was not associated with a worse graft function, greater proteinu...Continue Reading
References
Dec 1, 1992·Transplantation·I L NoronhaR Waldherr
Aug 1, 1989·Transplantation·M J RafteryJ S Cameron
Oct 1, 1986·Transplantation·D L McWhinnieP J Morris
Jan 1, 1994·Transplantation·D N RushJ Gough
Aug 1, 1993·Kidney International·K SolezP F Halloran
May 1, 1996·Kidney International·V K SharmaM Suthanthiran
Jan 1, 1997·Kidney International·D SerónJ Alsina
Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·J StrehlauT B Strom
Mar 26, 1998·Journal of the American Society of Nephrology : JASN·P NickersonD Rush
Jun 30, 1998·Transplantation·C LegendreH Kreis
Nov 10, 1998·Journal of the American Society of Nephrology : JASN·D RushJ Jeffery
Dec 29, 1998·Current Opinion in Nephrology and Hypertension·D N RushJ Gough
Jan 12, 1999·Transplantation·M L LipmanD N Rush
Feb 13, 1999·Kidney International·L C RacusenY Yamaguchi
Feb 25, 1999·Transplantation·E MazzucchiS Arap
Jul 15, 1999·Journal of the American Society of Nephrology : JASN·P C GrimmD N Rush
Aug 14, 1999·Journal of the American Society of Nephrology : JASN·P NickersonD Rush
Dec 1, 1999·Transplantation Proceedings·F V VeroneseR C Manfro
Jun 1, 2000·Transplantation·D SerónJ M Grinyó
Nov 25, 2000·Clinical Transplantation·K ShomoriH Ito
Mar 22, 2001·Transplantation·B J NankivellJ R Chapman
Jun 8, 2001·Clinical Transplantation·T IshimuraS Kamidono
Aug 15, 2002·Transplantation Proceedings·Helena Isoniemi
Aug 15, 2002·Transplantation Proceedings·C Ponticelli, G Banfi
Mar 15, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Christian MorathMartin Zeier
Citations
May 28, 2005·Transplantation Proceedings·G JungeP Neuhaus
Nov 10, 2005·Transplantation·Vincent AudardPhilippe Grimbert
Mar 15, 2006·Transplantation·Brian J Nankivell, Jeremy R Chapman
Oct 28, 2006·Drugs & Aging·Alain DuclosStuart M Flechner
Mar 28, 2013·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Claire CarteryNassim Kamar
Dec 21, 2010·Clinical and Experimental Nephrology·Kohsuke MasutaniMitsuo Iida
Dec 1, 2010·Kidney International. Supplement·Johan W de Fijter
Jun 19, 2015·The Tohoku Journal of Experimental Medicine·Dong Ho ShinJieun Oh
Dec 2, 2006·Transplant Immunology·P J Yates, M L Nicholson
Jul 13, 2005·Clinical Transplantation·Francisco Veríssimo VeroneseLuiz Felipe Gonçalves
Jun 27, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·B J Nankivell, J R Chapman
Oct 29, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Johan W de Fijter
Aug 21, 2008·Clinical Transplantation·Jose-Marie El-Amm, Scott A Gruber
Sep 3, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A ThierryG Touchard
Jul 15, 2015·Expert Opinion on Pharmacotherapy·Jamal BamoulidKlemens Budde
May 24, 2008·Transplantation·Dirk R J Kuypers