Prevalence and impact of pulmonary hypertension on patients with aortic stenosis who underwent transcatheter aortic valve replacement

The American Journal of Cardiology
Israel M BarbashRon Waksman

Abstract

Limited amount of data suggest that patients with aortic stenosis and pulmonary hypertension (PH) who undergo transcatheter aortic valve replacement (TAVR) experience decrease in PH postprocedure. Inconsistent use of systolic pulmonary artery pressure cut-off values in previous studies limits our ability to draw meaningful conclusions regarding the prognostic role of PH in assessment of TAVR candidates. A total of 415 consecutive patients who underwent TAVR were included in the present study. Two groups were compared based on receiver-operating characteristics curve analysis for the best SPAP value to predict outcome, yielding 2 study groups of no/mild PH (≤50 mm Hg; n = 172, 41%) versus moderate/severe PH (>50 mm Hg; n = 243, 59%). Demographics and co-morbidities were comparable between the 2 groups; however, right-sided cardiac failure (35% vs 19.8%, p = 0.02) and mitral regurgitation (18.4% vs 8.6%, p = 0.007) were more frequent in patients with moderate/severe PH. Procedural characteristics and complications were comparable between the groups. Although there was an early overall decrease in SPAP postprocedure, only 26% of moderate/severe patients with PH experienced a significant decrease in SPAP (>10 mm Hg). The 30-day (14...Continue Reading

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Citations

Mar 22, 2016·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Ricardo O EscárcegaRon Waksman
Feb 10, 2016·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Yan-Biao LiaoMao Chen
Mar 16, 2016·The Lancet. Respiratory Medicine·Marius M HoeperJ Simon R Gibbs
Jul 11, 2016·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Edward KoifmanRon Waksman
Jan 27, 2017·Cardiology and Therapy·Dagmar F Hernandez-Suarez, Angel López-Candales
Dec 31, 2016·Annals of the American Thoracic Society·Ryo YanagisawaKeiichi Fukuda
Dec 28, 2017·European Heart Journal·Javier BermejoUNKNOWN Sildenafil for Improving Outcomes after VAlvular Correction (SIOVAC) investigators
Mar 22, 2020·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Robert SchuelerChristoph Hammerstingl
Jan 29, 2019·Journal of the American Heart Association·Krishna K PatelMilind Y Desai
Jun 6, 2019·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Stefanie KeymelVerena Veulemans
Nov 7, 2017·European Heart Journal Cardiovascular Imaging·Franck LevyChristophe Tribouilloy
Jun 8, 2018·Frontiers in Cardiovascular Medicine·Micha T MaederHans Rickli
Mar 20, 2020·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·M S van MourikM M Vis
Jan 6, 2021·Journal of the American Heart Association·Javier BermejoUNKNOWN SIOVAC (“Sildenafil for Improving Outcomes after VAlvular Correction”) Investigators
Apr 23, 2020·The American Journal of Cardiology·Clément BèclePierre Lantelme

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