Prevalence and incidence of complications at diagnosis of T2DM and during follow-up by BMI and ethnicity: a matched case-control analysis

Cardiovascular Diabetology
Ebenezer S Owusu AdjahS Paul

Abstract

To estimate the risk of developing long-term major cardiovascular and renal complications in relation to levels of body mass index (BMI) in a population of White European (WE), African-Caribbean (AC), and South Asian (SA) patients with type 2 diabetes mellitus (T2DM). Patients with new diagnosis of T2DM, aged ≥ 18 years from January 2000 (n = 69,436) and their age-sex-ethnicity matched non-diabetic controls (n = 272,190) were identified from UK primary care database. Incidence rates ratios (IRRs) for non-fatal major cardiovascular events (MACE) and chronic kidney disease (CKD) in patients with T2DM compared to controls were estimated using multivariate Mantel-Cox model. Among normal weight patients with T2DM, WEs had significantly higher prevalence of cardiovascular multi-morbidity (95% CI 9.5, 11.3), compared to SAs (95% CI 4.8, 9.5). AC and SA overweight and obese patients had similar prevalence, while obese WEs had significantly higher prevalence. During a median 7 years of follow-up, risk of MACE was significantly higher for overweight (95% CI of IRR 1.50, 2.46) and obese (95% CI of IRR 1.49, 2.43) SAs compared to their WE counterparts. However, similar risk levels were observed for normal weight WEs and SAs, respectively. ...Continue Reading

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Citations

Jan 8, 2019·Diabetic Medicine : a Journal of the British Diabetic Association·L M Goff
Jun 13, 2019·Cardiovascular Diabetology·Quincy A HathawayJohn M Hollander
Apr 26, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Yingxin FuWenli Song
Jun 25, 2021·World Journal of Transplantation·G V Ramesh Prasad, Vaishnavi Bhamidi

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