Prevalence and mapping of hepatitis C infections among men who have sex with men in New York City.

PloS One
Hong-Van TieuB A Koblin

Abstract

Emerging sexually transmitted hepatitis C virus (HCV) epidemics among men who have sex with men (MSM) have been reported worldwide, with higher HCV infection rates among those who are HIV-infected. This study aims to determine prevalence of recent and chronic HCV infections among community-recruited MSM in New York City (NYC), map HCV infections by home, social, and sexual neighborhoods, and identify clusters of genetically linked HCV variants using phylogenetic analysis. The NYC M2M study recruited MSM via modified time-space, venue-based sampling and internet/mobile app-based recruitment during 2010-13. Participants completed a Google Earth map on neighborhoods of where they lived, socialized, and had sex in the last 3 months, an ACASI questionnaire, and a sexual network inventory about their sex partners. The men received HIV testing and provided serum samples. Testing on stored serum samples included HCV antibody and RNA viral load, HCV antibody avidity assay (avidity index <30% with positive viral load is considered recently infected), and HCV RNA extraction and amplification to generate a 432 base-pair region of Core/E1 for sequencing and phylogenetic analysis. Historic local controls were included in the phylogenetic ana...Continue Reading

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Citations

Dec 10, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marc G GhanyUNKNOWN AASLD-IDSA Hepatitis C Guidance Panel
Feb 6, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Caroline SchmidbauerThomas Reiberger
Feb 2, 2020·Journal of Racial and Ethnic Health Disparities·Laura D'AnnaUNKNOWN PPOWER Project Team
Dec 22, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Risha IrvinChloe L Thio
Nov 21, 2020·The Lancet. Gastroenterology & Hepatology·Fengyi JinAndrew E Grulich

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Methods Mentioned

BETA
ELISA
Assay

Software Mentioned

Google Earth
SAS
Geneious
Orasure
PhyML
ArcGIS

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