Prevalence and molecular characteristics of urinary and intestinal microsporidia infections in renal transplant recipients

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
Marta KiciaM Kvác

Abstract

Transplant recipients have been identified as a new risk group for microsporidia infection. We characterize for the first time the prevalence of microsporidia in intestinal and urinary tracts of renal transplant recipients. Molecular examination of 86 patients showed that 25.5% of them were infected; 86% were confirmed to have pathogens in their urine and 45.5% in stool. Among positive patients, 32% had microsporidia confirmed in both urine and stool. Genotyping revealed Encephalitozoon cuniculi (59%) and Enterocytozoon bieneusi (23%) monoinfections as well as coinfections with both species (18%). Moreover, we found diarrhoea and fever as symptoms significantly associated with microsporidia presence. Our results indicate that microsporidial infection should be considered in the assessment of renal transplant recipients, especially in the urinary tract, even if asymptomatic. Molecular identification of microsporidia species is relevant because of their different susceptibility for treatment.

References

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Citations

Apr 17, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marta KiciaAndrzej Pozowski
Aug 10, 2018·Expert Review of Anti-infective Therapy·Marta BodroCarlos Cervera
Apr 13, 2019·International Journal for Parasitology. Parasites and Wildlife·Sheng-Yong FengHong-Xuan He
Jun 9, 2021·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Jérôme DumortierUNKNOWN French Microsporidiosis Network
Jul 1, 2021·Clinical Microbiology Reviews·Bing HanLouis M Weiss

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