Prevalence and molecular epidemiology of mcr-1-positive Klebsiella pneumoniae in healthy adults from China.

The Journal of Antimicrobial Chemotherapy
Jiayue LuRong Zhang

Abstract

To investigate the nationwide prevalence of mcr-1-positive Klebsiella pneumoniae (MCRPKP) strains among healthy adults in China and identify their phenotypic and genomic characterizations. A total of 7401 rectal swab samples were collected from healthy individuals in 30 hospitals located in 30 provinces and municipalities of mainland China in 2016. Colistin-resistant bacteria were enriched in colistin-supplemented lysogeny broth. MCRPKP strains were isolated and characterized with MALDI-TOF MS, PCR analysis and antimicrobial susceptibility testing. The genomic characteristics of MCRPKP strains were determined by WGS and bioinformatics analysis. Seven MCRPKP strains and one mcr-1-positive Klebsiella variicola strain were selectively isolated from six locales (three from Henan and one from each of Tianjin, Jiangxi, Yunnan, Gansu and Tibet). Antimicrobial susceptibility testing results indicated that all mcr-1-positive strains were susceptible to meropenem, aztreonam and ceftazidime/avibactam. WGS analysis suggested these strains belonged to seven distinct STs: ST15, ST1425, ST1462, ST273, ST307, ST391 and ST37-SLV. mcr-1 genes were carried by diverse plasmids, including IncHI2 (n = 3), IncX4 (n = 2), IncHI2/IncN (n = 1), IncFIB (...Continue Reading

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Citations

Jan 9, 2021·Frontiers in Microbiology·Jianzhong FanXiaoting Hua
Mar 31, 2021·Nature Microbiology·Ricardo León-SampedroÁlvaro San Millán
Apr 6, 2021·Deutsches Ärzteblatt International·Robin KöckBirgit Walther
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