Prevalence and outcomes of fragility: a frailty-inflammation phenotype in children with chronic kidney disease

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Kristen SgambatAsha Moudgil

Abstract

Frailty is a condition of decreased physiologic reserve and increased vulnerability to stressors. Frailty in combination with inflammation has been associated with increased mortality risk in adults with advanced chronic kidney disease (CKD). This study aimed to investigate prevalence and outcomes associated with a frailty-inflammation phenotype, or "fragility," in children with CKD. We analyzed 557 children (age 6-19 years, eGFR 30-90 ml/min/1.73 m2) from the Chronic Kidney Disease in Children (CKiD) study. Based on adult models, the CKiD fragility model included four indicators: (1) suboptimal growth/weight gain (BMI < 5th percentile-for-height-age, deceleration ≥ 10 BMI-for-height-age percentiles/1 year, height-for-age percentile < 3rd or deceleration ≥ 10 height percentiles/1 year); (2) low muscle mass (mid-upper-arm circumference < 5th percentile or deceleration ≥ 10 percentiles/1 year); (3) fatigue (parent/child report); (4) inflammation (CRP > 3 mg/l). Logistic regression was used to evaluate association of fragility indicators with three adverse outcomes: frequent infection (> 1 per year/3 years), hospitalization (any), and rapid CKD progression (decline in eGFR > 30% or initiation of renal replacement therapy within 3 ...Continue Reading

References

Mar 17, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·L P FriedUNKNOWN Cardiovascular Health Study Collaborative Research Group
Sep 1, 2005·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Kenneth RockwoodArnold Mitnitski
Aug 19, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Susan L FurthBradley A Warady
Oct 19, 2007·Journal of the American Society of Nephrology : JASN·Kirsten L JohansenNancy G Kutner
Jul 2, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Linda P FriedKaren Bandeen-Roche
Nov 26, 2010·Clinics in Geriatric Medicine·Xu YaoSean X Leng
Jun 27, 2012·Archives of Internal Medicine·Yeran BaoKirsten L Johansen
May 29, 2013·Journal of the American Geriatrics Society·Mara A McAdams-DeMarcoDorry L Segev
Oct 24, 2013·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Robert W KrellPreeti N Malani
Feb 8, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Alison G AbrahamSusan L Furth
Jun 18, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J C LaiK Covinsky
Sep 29, 2015·International Urology and Nephrology·Carlos G MussoJuan F Macías Núñez
Nov 13, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ariel TroibYael Segev
Dec 29, 2015·Advances in Chronic Kidney Disease·Joseph R BergerS Susan Hedayati
Jun 28, 2016·Clinical Journal of the American Society of Nephrology : CJASN·Marije H KallenbergSimon P Mooijaart
Nov 30, 2016·Journal of Cachexia, Sarcopenia and Muscle·Rizhen YuZhaoyong Hu
Apr 11, 2017·Biochemical and Biophysical Research Communications·Li-Jing SunGeng-Ru Jiang
Feb 27, 2018·The Journal of Pediatrics·Eberhard LurzBinita M Kamath
Apr 8, 2018·International Journal of Paleopathology·Samantha L Yaussy, Sharon N DeWitte
Apr 13, 2018·Clinical Kidney Journal·Andrew C NixonAjay Dhaygude
Dec 7, 2018·Clinical Chemistry·Ralph Stewart
Dec 28, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sean G KellyFrank J Palella
Jan 24, 2019·Annals of Surgery·Christine E HaugenJennifer C Lai

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Citations

Dec 14, 2019·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Lesley Rees
Jan 15, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Julien HoganLarry A Greenbaum
Feb 4, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Vasiliki KaravaNikoleta Printza
Feb 17, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Adrian PostCasper F M Franssen
Feb 19, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Vasiliki KaravaNikoleta Printza
Mar 22, 2021·Journal of Translational Medicine·Adrian PostCasper F M Franssen
Sep 23, 2020·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Arpana IyengarAnil Vasudevan

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