Prevalence and Overlap of Potential Embolic Sources in Patients With Embolic Stroke of Undetermined Source

Journal of the American Heart Association
George NtaiosPatrik Michel

Abstract

Background We aimed to assess the prevalence and degree of overlap of potential embolic sources (PES) in patients with embolic stroke of undetermined source (ESUS). Methods and Results In a pooled data set derived from 3 prospective stroke registries, patients were categorized in ≥1 groups according to the PES that was/were identified. We categorized PES as follows: atrial cardiopathy, atrial fibrillation diagnosed during follow-up, arterial disease, left ventricular disease, cardiac valvular disease, patent foramen ovale, and cancer. In 800 patients with ESUS (43.1% women; median age, 67.0 years), 3 most prevalent PES were left ventricular disease, arterial disease, and atrial cardiopathy, which were present in 54.4%, 48.5%, and 45.0% of patients, respectively. Most patients (65.5%) had >1 PES, whereas only 29.7% and 4.8% of patients had a single or no PES, respectively. In 31.1% of patients, there were ≥3 PES present. On average, each patient had 2 PES (median, 2). During a median follow-up of 3.7 years, stroke recurrence occurred in 101 (12.6%) of patients (23.3 recurrences per 100 patient-years). In multivariate analysis, the risk of stroke recurrence was higher in the atrial fibrillation group compared with other PES, but ...Continue Reading

Associated Clinical Trials

May 9, 2016·George Ntaios

References

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Citations

Dec 13, 2019·Stroke; a Journal of Cerebral Circulation·George NtaiosPatrik Michel
Jan 3, 2020·Stroke; a Journal of Cerebral Circulation·Hooman KamelJeff S Healey
May 20, 2020·International Journal of Stroke : Official Journal of the International Stroke Society·George NtaiosPatrik Michel
Aug 13, 2020·Stroke; a Journal of Cerebral Circulation·Hooman KamelIván Díaz
Apr 17, 2020·Stroke; a Journal of Cerebral Circulation·George NtaiosUNKNOWN NAVIGATE ESUS Investigators
Sep 3, 2020·Thrombosis and Haemostasis·Ioannis A LeventisGeorge Ntaios
Mar 4, 2020·International Journal of Stroke : Official Journal of the International Stroke Society·Ioannis LeventisGeorge Ntaios
Sep 13, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G NtaiosP Michel
Oct 7, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A Kitsiou, W-R Schäbitz
Jan 10, 2021·European Journal of Internal Medicine·Dimitrios SagrisHaralampos Milionis
Nov 3, 2020·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·George NtaiosPatrik Michel
Jan 29, 2021·Stroke; a Journal of Cerebral Circulation·Babak B NaviLisa M DeAngelis
Apr 6, 2020·The American Journal of Medicine·Wolf-Rüdiger SchäbitzMarc Fisher
Mar 19, 2021·Deutsche medizinische Wochenschrift·Alkisti KitsiouAndreas Rogalewski
Mar 9, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Hanan AlhazmiLaura Mechtouff
Apr 26, 2021·Internal and Emergency Medicine·Dimitrios SagrisGeorge Ntaios
Apr 1, 2021·International Journal of Stroke : Official Journal of the International Stroke Society·Jon Davis PerkinsSaadat Ilyas
May 5, 2021·Brain and Behavior·Jing ChenWenhong Liu
Apr 20, 2021·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Tony Y W LiChing-Hui Sia
Jun 6, 2021·Heart and Vessels·Naomi HirotaTakeshi Yamashita
Jun 23, 2021·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Yoon-Kyung LeeJae-Kwan Cha
Aug 27, 2021·Frontiers in Cardiovascular Medicine·Yuye NingGuoliang Li
Oct 29, 2021·Stroke; a Journal of Cerebral Circulation·Aditya BhatTimothy C Tan
Mar 12, 2021·Minerva Cardiology and Angiology·Gaston A Rodriguez-GranilloPedro Lylyk

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Clinical Trials Mentioned

NCT02766205

Software Mentioned

R package

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