PMID: 22358416Feb 24, 2012Paper

Prevalence and patterns of HIV transmitted drug resistance in Guatemala

Revista Panamericana De Salud Pública = Pan American Journal of Public Health
Santiago Avila-RíosGustavo Reyes-Terán

Abstract

To assess human immunodeficiency virus (HIV) diversity and the prevalence of transmitted drug resistance (TDR) in Guatemala. One hundred forty-five antiretroviral treatment-naïve patients referred to the Roosevelt Hospital in Guatemala City were enrolled from October 2010 to March 2011. Plasma HIV pol sequences were obtained and TDR was assessed with the Stanford algorithm and the World Health Organization (WHO) TDR surveillance mutation list. HIV subtype B was highly prevalent in Guatemala (96.6%, 140/145), and a 2.8% (4/145) prevalence of BF1 recombinants and 0.7% (1/145) prevalence of subtype C viruses were found. TDR prevalence for the study period was 8.3% (12/145) with the Stanford database algorithm (score > 15) and the WHO TDR surveillance mutation list. Most TDR cases were associated with non-nucleoside reverse transcriptase inhibitors (NNRTIs) (83.3%, 10/12); a low prevalence of nucleoside reverse transcriptase inhibitors and protease inhibitors was observed in the cohort (< 1% for both families). Low selection of antiretroviral drug resistance mutations was found, except for NNRTI-associated mutations. Major NNRTI mutations such as K101E, K103N, and E138K showed higher frequencies than expected in ART-naïve populatio...Continue Reading

Citations

Oct 28, 2014·AIDS Research and Human Retroviruses·Santiago Avila-RíosGustavo Reyes-Terán
Jun 21, 2013·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Á HolguínG Escobar
Sep 30, 2017·The Journal of Antimicrobial Chemotherapy·Claudia García-MoralesUNKNOWN HIVDR MexNet Group
Apr 6, 2018·AIDS Research and Human Retroviruses·Pedro Gerardo Hernandez-SanchezChristian Alberto Garcia-Sepulveda

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