Prevalence and persistence of chromosomal damage and susceptible genotypes of metabolic and DNA repair genes in Chinese vinyl chloride-exposed workers.

Carcinogenesis
Fang JiDavid C Christiani

Abstract

Vinyl chloride (VC) was classified as a group 1 carcinogen by IARC in 1987. Although the relationship between VC exposure and liver cancer has been established, the mechanism of VC-related carcinogenesis remains largely unknown. Previous epidemiological studies have shown that VC exposure is associated with increased genotoxicity in humans. To explore chromosomal damage and its progression, and their association to genetic susceptibility, we investigated 402 workers exposed to VC, a 77 VC-exposed cohort and 141 unexposed subjects. We measured the frequencies of cytokinesis-block micronucleus (CBMN) to reflect chromosomal damage and conducted genotyping for six xenobiotic metabolisms and five DNA repair genes' polymorphism. Data indicate that 95% of the control workers had CBMN frequencies </=3 per thousand, whereas VC-exposed workers had the 3.73-fold increase compared with the controls. Among the cohort workers who were followed from 2004 to 2007, the mean CBMN frequency was higher in 2007 than in 2004 with ratio of 2.08. Multiple Poisson regression analysis showed that mean CBMN frequencies were significantly elevated for the intermediate and high exposure groups than the low. Exposed workers with CYP2E1 or XRCC1 variance sho...Continue Reading

References

Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Dec 3, 1999·Science·T Lindahl, R D Wood
Dec 13, 2000·Mutation Research·M Fenech
Apr 24, 2001·Environmental and Molecular Mutagenesis·A Ronen, B W Glickman
Jun 1, 2002·Occupational and Environmental Medicine·R-H WongT-J Cheng
Apr 4, 2003·Japanese Journal of Clinical Oncology·Akira Yokoyama, Tai Omori
Aug 24, 2004·Oncogene·Paolo Vineis
May 4, 2005·Nucleic Acids Research·Reto Brem, Janet Hall
Jul 12, 2005·Human Genomics·Vasilis Vasiliou, Daniel W Nebert
Oct 13, 2005·International Journal of Hygiene and Environmental Health·Shoumin ZhuZhaolin Xia
Nov 15, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Zhongbin ZhangZhaolin Xia
May 17, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Micheline Kirsch-VoldersMichael Fenech
Dec 22, 2006·Carcinogenesis·Ann G SchwartzMichele L Cote
Mar 27, 2007·Journal of Human Genetics·Jennifer SchindlerPaul W Brandt-Rauf
Aug 22, 2008·International Journal of Occupational Medicine and Environmental Health·Ai-Hong WangZhao-Lin Xia
Jun 30, 2011·Human Genomics·Brian JacksonVasilis Vasiliou

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Citations

Dec 29, 2012·Archives of Environmental Contamination and Toxicology·Alagamuthu Karthick KumarKeshavarao Sasikala
Jan 28, 2014·International Journal of Occupational Medicine and Environmental Health·Yong LiZhao-Lin Xia
Jul 1, 2017·American Journal of Human Biology : the Official Journal of the Human Biology Council·Alfredo SantovitoPiero Cervella
May 2, 2019·The International Journal of Occupational and Environmental Medicine·Salim ShayakhmetovAlexey Merinov
May 16, 2018·Environmental and Molecular Mutagenesis·Li-Bo YuZhao-Lin Xia

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