Prevalence and predictors of chronic health conditions after hematopoietic cell transplantation: a report from the Bone Marrow Transplant Survivor Study.

Blood
Can-Lan SunSmita Bhatia

Abstract

Long-term survival is now an expected outcome after hematopoietic cell transplantation (HCT). However, the burden of morbidity long-term after HCT remains unknown. We examined the magnitude of risk of chronic health conditions reported by 1022 HCT survivors and their siblings (n = 309). A severity score (grades 1 [mild] through 4 [life-threatening]) was assigned to each health condition using the Common Terminology Criteria for Adverse Events, Version 3. Sixty-six percent of the HCT survivors reported at least one chronic condition; 18% reported severe/life-threatening conditions; comparable values in siblings were 39% and 8%, respectively (P < .001). The cumulative incidence of a chronic health condition among HCT survivors was 59% (95% confidence interval [CI], 56%-62%) at 10 years after HCT; for severe/life-threatening conditions or death from chronic health conditions, the 10-year cumulative incidence approached 35% (95% CI, 32%-39%). HCT survivors were twice as likely as siblings to develop a chronic condition (95% CI, 1.6-2.1), and 3.5 times to develop severe/life-threatening conditions (95% CI, 2.3-5.4). HCT survivors with chronic graft-versus-host disease were 4.7 times as likely to develop severe/life-threatening condi...Continue Reading

Associated Clinical Trials

Jul 30, 2018·Meral Boşnak Güçlü

References

Aug 29, 1998·Bone Marrow Transplantation·A C MertensJ P Neglia
Jun 13, 2000·Bone Marrow Transplantation·A D LouieS Bhatia
Aug 16, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C CutlerJ H Antin
Jul 9, 2002·British Journal of Haematology·Alison D Leiper
Jul 9, 2002·British Journal of Haematology·Bernadette M D Brennan, Stephen M Shalet
Nov 15, 2002·International Journal of Hematology·Jean E Sanders
Nov 26, 2002·Hematology·John R WingardH Joachim Deeg
Jan 4, 2003·Blood·Gérard SociéUNKNOWN Late Effects Working Party of the European Study Group for Blood and Marrow Transplantation
Mar 23, 2004·American Journal of Epidemiology·Guangyong Zou
May 15, 2004·British Journal of Haematology·Meghan A Higman, Georgia B Vogelsang
Oct 13, 2006·The New England Journal of Medicine·Kevin C OeffingerUNKNOWN Childhood Cancer Survivor Study
Sep 25, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Navneet S MajhailK Scott Baker
Sep 24, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Saro H ArmenianSmita Bhatia
Oct 31, 2008·Blood·J Douglas RizzoH Joachim Deeg

❮ Previous
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Citations

Jun 13, 2013·JAMA : the Journal of the American Medical Association·Melissa M HudsonLeslie L Robison
Nov 11, 2011·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Sheraz R MarkarRahul V Patel
Dec 7, 2013·Nature Reviews. Cancer·Leslie L Robison, Melissa M Hudson
Feb 11, 2012·Journal of Experimental & Clinical Cancer Research : CR·Lubica RoziakovaBeata Mladosievicova
Dec 8, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nandita KheraStephanie J Lee
Sep 26, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Karen L SyrjalaStephanie J Lee
Aug 30, 2012·Haematologica·Norbert-Claude GorinUNKNOWN Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT)
Nov 16, 2011·Hämostaseologie·G Stussi, D A Tsakiris
Jan 10, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Gemma DyerIan Kerridge
Dec 22, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Annemarie M J BraamseKaren L Syrjala
Sep 3, 2013·Expert Review of Hematology·André Tichelli, Alicia Rovó
Sep 25, 2012·Molecular Immunology·David C Kilpatrick
Jan 10, 2012·Seminars in Hematology·Alicia RovóUNKNOWN Late Effects Working Party of the European Group for Blood and Marrow Transplantation
Oct 16, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Christine N DuncanMohamed L Sorror
Feb 26, 2016·Current Treatment Options in Cardiovascular Medicine·Anne BlaesPeter Hurley
May 25, 2013·Cancer·Daniel J LenihanDaniela Cardinale
Oct 30, 2013·Cancer·Saro H Armenian, Eric J Chow
Sep 1, 2015·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·R Lajiness-O'NeillJ A Connelly
Sep 16, 2015·Cancer·Zhuoyan LiAlicia Rovó
Jun 2, 2015·Bone Marrow Transplantation·E S TonorezosW L Schaffer
Feb 26, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Eric J ChowK Scott Baker
Sep 24, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Mohamad MohtyBipin N Savani
Aug 7, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·David BuchbinderNavneet S Majhail
Dec 21, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Prakash SatwaniMitchell S Cairo
Apr 16, 2013·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Can-Lan SunSmita Bhatia
Jul 19, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Smita BhatiaJohn A Hansen
Feb 12, 2013·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Xiao-Dong MoXiao-Jun Huang
Jun 26, 2013·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·André Tichelli, Alicia Rovó

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