PMID: 22579012May 15, 2012Paper

Prevalence and predictors of potential drug-drug interactions in the elderly: a cross-sectional study in the brazilian primary public health system

Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Société Canadienne Des Sciences Pharmaceutiques
Paulo Roque Obreli NetoRoberto Kenji Nakamura Cuman

Abstract

The primary objective of this study was to investigate the prevalence of clinically important potential drug-drug interactions (DDIs) in elderly patients attending the public primary health care system in Brazil. The secondary objective was to investigate possible predictors of potential DDIs. A cross-sectional study was carried out in 5 Brazilian cities located in the Ourinhos Micro-region, Sao Paulo State, between November 2010 and April 2011. The selected sample was divided according to the presence (exposed) or absence (unexposed) of one or more potential DDIs (defined as the presence of a minimum 5-day overlap in supply of an interacting drug pair). Data were collected from medical prescriptions and patients' medical records. Potential DDIs (rated major or moderate) were identified using 4 DDI-checker programs. Logistic regression analysis was used to study potential DDI predictors. The prevalence of clinically important potential DDIs found during the study period was 47.4%. Female sex (OR = 2.49 [95% CI 2.29-2.75]), diagnosis of ≥ 3 diseases (OR = 6.43 [95% CI 3.25-12.44]), and diagnosis of hypertension (OR = 1.68 [95% CI 1.23-2.41]) were associated with potential DDIs. The adjusted OR increased from 0.90 [95% CI 0.82-1....Continue Reading

Citations

Nov 23, 2013·Journal of Thrombosis and Thrombolysis·Camilo Molino GuidoniLeonardo Regis Leira Pereira
Jun 22, 2017·Geriatrics & Gerontology International·Thalyta Renata Araújo SantosRita Goreti Amaral
Dec 23, 2014·European Journal of Clinical Pharmacology·Tina RoblekMitja Lainscak
Sep 7, 2016·Revista latino-americana de enfermagem·Maria Cristina Soares Rodrigues, Cesar de Oliveira
Aug 3, 2017·Issues in Mental Health Nursing·Tatiana Longo BorgesAdriana Inocenti Miasso
Jun 4, 2019·European Journal of Hospital Pharmacy. Science and Practice·Yugandhar BethiBatmanabane Gitanjali
Oct 31, 2019·Ciência & saúde coletiva·Janaina da Silva SantosMaria Luiza Garcia Rosa
Jun 7, 2013·European Journal of Clinical Pharmacology·Srecko MarusicNives Gojo-Tomic
Feb 7, 2018·BioMed Research International·Fitsum Sebsibe TeniYonas Getaye Tefera

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