Prevalence and predictors of suboptimal peak inspiratory flow rate in COPD patients

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Hadeer S HarbMohamed E A Abdelrahim

Abstract

The aim of this study was to determine prevalence and possible clinical predictors of suboptimal peak inspiratory flow rate (PIFR) with different dry powder inhalers. PIFR was measured across all resistance ranges of In-Check Dial® in 180 chronic obstructive pulmonary disease (COPD) subjects before hospital discharge. COPD subjects were defined as suboptimal if measured PIFR was suboptimal with any resistance representative of specific inhalers (R1-R5). Demographics and clinical data were collected, including COPD Assessment Test (CAT) and modified Medical Research Council (mMRC) scores, Global Initiative for Obstructive Lung Disease (GOLD) stage spirometry by Spirodoc® and peak flow meter measurements with portable peak inspiratory and expiratory flow meters. All were correlated with In-Check Dial PIFRs. Suboptimal PIFR was 44.44% prevalent in COPD subjects. 55% of the suboptimal cohort was female which represent 57.14% of the total female population in the study. The distribution of suboptimal PIFR included 43.75% with R1, 67.5% with R2, 100% with R3, 13.75% with R4, and 21.25% with R5. In the suboptimal cohort, CAT score was significantly higher and spirometry demonstrated significantly lower lung function results compared t...Continue Reading

Citations

Jul 3, 2020·Experimental Lung Research·Hadeer S HarbMohamed E A Abdelrahim
Jul 24, 2020·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Timothy R Hudd
Aug 19, 2020·International Journal of Clinical Practice·Xingai JiaoYufang Zhan
Dec 10, 2020·Journal of Clinical Medicine·Cristina Represas-RepresasAlberto Fernández-Villar
Dec 6, 2020·International Journal of Clinical Practice·Hadeer S HarbMohamed E A Abdelrahim
Dec 7, 2020·International Journal of Clinical Practice·Yasmin M MadneyMohamed E A Abdelrahim
Feb 10, 2021·International Journal of Clinical Practice·Hadeer S HarbMohamed E A Abdelrahim
Feb 8, 2021·International Journal of Clinical Practice·Mona A AbdelrahmanMohamed E A Abdelrahim
Mar 27, 2021·Clinical Drug Investigation·Mathieu MolimardIvan Nikolaev
Apr 5, 2021·Chest·Donald A Mahler, David M G Halpin
Jul 17, 2021·Frontiers in Pharmacology·Shih-Yu ChenJung-Yien Chien
Sep 15, 2021·International Journal of Clinical Practice·Hadeer S HarbMohamed E A Abdelrahim

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