Abstract
Anemia is common in patients with congestive heart failure (CHF), although its etiology and pathophysiology remain largely unexplained. The purpose of this study was to examine the prognostic significance of a low hematocrit (Hct) in patients with CHF and the possible role of angiotensin-converting enzyme inhibition in anemia development. Hct was measured at the time of enrollment of 160 patients with CHF, mean age 56 +/- 12 years, in New York Heart Association (NYHA) functional class 2.6 +/- 0.7 and with left ventricular ejection fraction of 20 +/- 9%. They were randomized to standard (mean: 17.9 +/- 4.3 mg/day) or high (mean: 42 +/- 19.3 mg/day) doses of enalapril. The follow-up duration was 2 years. Cox regression models were used to identify prognostic factors, and correlations among individual variables were tested. Mean baseline Hct was 42.7 +/- 5%. In multivariate analyses, low Hct (p = 0.036), older age (p = 0.022) and low systolic blood pressure (p = 0.032) were independent predictors of death within 2 years. A correlation was found between baseline Hct and NYHA class (Spearman's correlation coefficient: -0.183, p = 0.008). A significant decrease in Hct from 43.2 +/- 4.9% at baseline to 40.7 +/- 4.4% at 2 years was obs...Continue Reading
References
Jun 12, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·S AlbitarB Bourgeon
Aug 27, 1998·The New England Journal of Medicine·A BesarabD A Goodkin
Aug 26, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·I C Macdougall
Jun 7, 2000·Journal of the American College of Cardiology·D S SilverbergA Iaina
Dec 29, 2000·Journal of the American College of Cardiology·J N NanasS D Moulopoulos
Nov 28, 2002·European Journal of Heart Failure·Donald S SilverbergAdrian Iaina
Jan 23, 2003·Circulation·Justin A EzekowitzPaul W Armstrong
Jan 23, 2003·Circulation·Ana-Silvia AndroneDonna M Mancini
Jan 23, 2003·Circulation·Donna M ManciniAna-Silvia Androne
Feb 18, 2004·Current Topics in Medicinal Chemistry·K P MarathiasD V Vlahakos
Mar 10, 2004·Journal of Cardiac Failure·Michel Komajda
Mar 10, 2004·Journal of Cardiac Failure·Darlington O Okonko, Stefan D Anker
Mar 10, 2004·Journal of Cardiac Failure·Stuart D KatzKatarzyna Hryniewicz
Apr 30, 2004·The Journal of Thoracic and Cardiovascular Surgery·Sharon Hunt
May 8, 2004·American Heart Journal·Klaus K A WitteAndrew L Clark
Jun 12, 2004·European Heart Journal·Rakesh SharmaStefan D Anker
Citations
Mar 26, 2008·Heart Failure Reviews·Garry J Handelman, Nathan W Levin
Sep 4, 2008·Current Heart Failure Reports·Haroon A FarazJalal K Ghali
Sep 4, 2012·Current Heart Failure Reports·Shanti Gunawardena, Mark E Dunlap
Aug 5, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Sanae HamaguchiUNKNOWN JCARE-CARD Investigators
Apr 18, 2009·Future Cardiology·John V TerrovitisJohn N Nanas
Jul 16, 2010·Heart Failure Clinics·Richard K Spence
Mar 24, 2009·Medicina clínica·Jorge Grau AmorósUNKNOWN Investigadores del Estudio GESAIC
Apr 24, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Koracevic Goran
Sep 6, 2007·The Journal of Clinical Hypertension·Domenic A Sica, Rosemarie Mannino
Dec 19, 2006·Journal of the American College of Cardiology·John N NanasMaria I Anastasiou-Nana
Aug 30, 2008·Journal of the American College of Cardiology·Hessel F GroenveldPeter van der Meer
Mar 12, 2011·American Heart Journal·Sameer AtherBiykem Bozkurt
Jul 17, 2014·Circulation. Heart Failure·Eileen O'MearaSimon de Denus
Jun 18, 2009·Current Opinion in Cardiology·Jalal K Ghali