Prevalence and prognostic significance of anemia in patients with congestive heart failure treated with standard vs high doses of enalapril

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
John V TerrovitisJohn N Nanas

Abstract

Anemia is common in patients with congestive heart failure (CHF), although its etiology and pathophysiology remain largely unexplained. The purpose of this study was to examine the prognostic significance of a low hematocrit (Hct) in patients with CHF and the possible role of angiotensin-converting enzyme inhibition in anemia development. Hct was measured at the time of enrollment of 160 patients with CHF, mean age 56 +/- 12 years, in New York Heart Association (NYHA) functional class 2.6 +/- 0.7 and with left ventricular ejection fraction of 20 +/- 9%. They were randomized to standard (mean: 17.9 +/- 4.3 mg/day) or high (mean: 42 +/- 19.3 mg/day) doses of enalapril. The follow-up duration was 2 years. Cox regression models were used to identify prognostic factors, and correlations among individual variables were tested. Mean baseline Hct was 42.7 +/- 5%. In multivariate analyses, low Hct (p = 0.036), older age (p = 0.022) and low systolic blood pressure (p = 0.032) were independent predictors of death within 2 years. A correlation was found between baseline Hct and NYHA class (Spearman's correlation coefficient: -0.183, p = 0.008). A significant decrease in Hct from 43.2 +/- 4.9% at baseline to 40.7 +/- 4.4% at 2 years was obs...Continue Reading

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Citations

Mar 26, 2008·Heart Failure Reviews·Garry J Handelman, Nathan W Levin
Sep 4, 2008·Current Heart Failure Reports·Haroon A FarazJalal K Ghali
Sep 4, 2012·Current Heart Failure Reports·Shanti Gunawardena, Mark E Dunlap
Apr 18, 2009·Future Cardiology·John V TerrovitisJohn N Nanas
Jul 16, 2010·Heart Failure Clinics·Richard K Spence
Mar 24, 2009·Medicina clínica·Jorge Grau AmorósUNKNOWN Investigadores del Estudio GESAIC
Apr 24, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Koracevic Goran
Sep 6, 2007·The Journal of Clinical Hypertension·Domenic A Sica, Rosemarie Mannino
Dec 19, 2006·Journal of the American College of Cardiology·John N NanasMaria I Anastasiou-Nana
Aug 30, 2008·Journal of the American College of Cardiology·Hessel F GroenveldPeter van der Meer
Jun 18, 2009·Current Opinion in Cardiology·Jalal K Ghali

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