PMID: 8938215Jan 1, 1996Paper

Prevalence and prognostic significance of proteinuria in patients with lung cancer

Acta Oncologica
L M Pedersen, N Milman

Abstract

The purpose of the present study was to ascertain the prevalence and prognostic significance of proteinuria in patients with lung cancer. Results of urinary dipstick testing were retrospectively reviewed in 1026 consecutive out-patients with histologically proven primary lung cancer and 475 consecutive out-patients with benign pulmonary disorders. Postoperative urinary dipstick test results were recorded in 243 surgically resected patients. Proteinuria was significantly more frequent in patients with lung cancer than in controls (30.1% vs 8.8%, p < 0.0001). The presence of proteinuria was significantly correlated with advanced disease stage (p < 0.0001). The frequency of proteinuria was significantly higher in patients with small cell carcinoma than in patients with other histologic types (p < 0.01). In the surgically resected patients, preoperative and postresection proteinuria occurred in 25.5% and 10.7% respectively (p < 0.0001). Patients with malignancies and proteinuria had significantly poorer survival than patients with normal urinary protein excretion (p < 0.0001). In a multivariate analysis including TNM stage, histologic type, sex, and age, proteinuria continued to be a significant predictor of reduced survival time. ...Continue Reading

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Citations

Jun 29, 2000·Medical Oncology·L M PedersenK H Stokholm
Jun 13, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L M Pedersen, N Milman
Dec 22, 1999·British Journal of Haematology·L M Pedersen, P G Sørensen
Apr 29, 2005·International Journal of Clinical Practice·I DilekR Erkoç
Feb 8, 2008·Journal of the American Society of Nephrology : JASN·Lone JørgensenBjarne K Jacobsen
Jun 20, 2000·Acta Oncologica·L M Pedersen, P G Sørensen
Feb 8, 2005·Clinical Lung Cancer·Peyman Sardari NiaPaul Van Schil
Sep 13, 2002·Chest·Michael D BrundageWilliam J Mackillop
Aug 16, 2000·Scandinavian Journal of Clinical and Laboratory Investigation·J Watine
Aug 7, 2013·Yonsei Medical Journal·Min Jee KimSoo Wan Kim

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