Prevalence and risk factors for congenital diaphragmatic hernia: A global view.

Journal of Pediatric Surgery
Monica PaolettiAugusto Zani

Abstract

To determine the global prevalence for congenital diaphragmatic hernia (CDH) and identify CDH-related risk factors. Using a defined strategy, a systematic review of the literature was conducted according to PRISMA guidelines, searching for population-based epidemiological studies to evaluate the prevalence of CDH globally and per country. Studies containing overlapping populations or timeframes were excluded. CDH-related risk factors were calculated by meta-analysis using RevMan5.3 and expressed as risk ratio and 95% confidence interval. Prevalence: Of 8230 abstracts screened, 30 full-text articles published between 1980 and 2019 were included. The overall prevalence of CDH was 2.3 in 10,000 births (16,710 CDH babies in 73,663,758 livebirths). From 9 studies we found that male sex [RR 1.38 (1.05-1.80), p=0.02] and maternal age >35 years [RR 1.69 (1.26-2.25), p=0.0004] were associated with CDH. Conversely, maternal black ethnicity resulted as a protective factor [RR 0.82 (0.77-0.89, p<0.00001]. This study reveals that there is a worldwide paucity of population-based studies, and those studies that report on prevalence and risk factors come from a small number of countries. The prevalence of CDH varies within and across geographi...Continue Reading

Citations

Dec 1, 2020·Annals of Epidemiology·Maria D PolitisUNKNOWN International Clearinghouse for Birth Defects Surveillance and Research
Jun 16, 2021·Journal of Perinatology : Official Journal of the California Perinatal Association·Yoko KawanishiHiroomi Okuyama
Jul 20, 2021·Radiology Case Reports·Muhammad Zahid Abdul MuienYong Guang Teh

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