Prevalence and risk factors for CTX-M gram-negative bacteria in hospitalized patients at a tertiary care hospital in Kilimanjaro, Tanzania

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
Tolbert SondaGibson S Kibiki

Abstract

Emergence and spread of extended spectrum beta-lactamase (ESBL)-producing gram-negative bacteria, mainly due to CTX-M, is a major global public health problem. Patients infected with ESBL-producing gram-negative bacteria have an increased risk of treatment failure and death. We investigated the prevalence and risk factors for CTX-M gram-negative bacteria isolated from clinical specimens of patients hospitalized at a tertiary care hospital in Kilimanjaro, Tanzania. Isolated gram-negative bacteria from inpatients admitted at Kilimanjaro Christian Medical Centre (KCMC) between August 2013 and August 2015 were fully genome sequenced. The prevalence of ESBL-producing gram-negative bacteria was determined based on the presence of blaCTX-M. The odds ratio (OR) and risk factors for ESBL-producing gram-negative bacteria due to CTX-M were assessed using logistic regression models. The overall CTX-M prevalence (95% CI) was 13.6% (10.1-18.1). Adjusted for other factors, the OR of CTX-M gram-negative bacteria for patients previously hospitalized was 0.26 (0.08-0.88), p = 0.031; the OR for patients currently on antibiotics was 4.02 (1.29-12.58), p = 0.017; the OR for patients currently on ceftriaxone was 0.14 (0.04-0.46), p = 0.001; and the ...Continue Reading

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Citations

Sep 25, 2019·Antibiotics·Angus Nnamdi OliJude Nnaemeka Okoyeh
Sep 8, 2020·Antimicrobial Resistance and Infection Control·Pius G HorumpendeQuirijn de Mast
Aug 15, 2019·Implementation Science : IS·Nina Van GoethemAnnie Robert
Dec 5, 2020·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Joel ManyahiBjørn Blomberg
Jun 15, 2021·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Onduru G OnduruSusan F Rumisha

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Methods Mentioned

BETA
Assay
PCR

Software Mentioned

OpenClinica
Stata

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