Prevalence and risk factors for extended-spectrum β-lactamase-producing Escherichia coli causing community-onset urinary tract infections in Colombia

Enfermedades infecciosas y microbiología clínica
Victor M BlancoMaria Virginia Villegas

Abstract

Urinary tract infections (UTI) are common in the community. However, information of resistant isolates in this context is limited in Latin America. This study aims to determine the prevalence and risk factors associated with community-onset UTI (CO-UTI) caused by extended-spectrum β-lactamase (ESBL)-Producing Escherichia coli in Colombia. A case-control study was conducted between August and December of 2011 in three Colombian tertiary-care institutions. All patients who were admitted to the Emergency Department with a probable diagnosis of CO-UTI were invited to participate. All participating patients were asked for a urine sample. ESBL confirmatory test, antibiotic susceptibility, and molecular epidemiology were performed in these E.coli isolates (Real Time-PCR for bla genes, repetitive element palindromic PCR [rep-PCR], multilocus sequence typing [MLST] and virulence factors by PCR). Clinical and epidemiological information was recorded, and a statistical analysis was performed. Of the 2124 recruited patients, 629 had a positive urine culture, 431 of which grew E.coli; 54 were positive for ESBL, of which 29 were CTX-M-15. The majority of ESBL isolates were susceptible to ertapenem, phosphomycin and amikacin. Complicated UTI ...Continue Reading

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Citations

Jan 4, 2018·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Claudia Soria SegarraMonica Cartelle Gestal
Sep 13, 2017·Antimicrobial Agents and Chemotherapy·Sandra Yamile SaavedraCarolina Duarte
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Dec 5, 2020·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Joel ManyahiBjørn Blomberg
Aug 28, 2021·Antibiotics·Virginia Núñez-SamudioIván Landires

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