Prevalence and risk factors for lung involvement on low-dose chest CT (LDCT) in a paucisymptomatic population of 247 patients affected by COVID-19.

Insights Into Imaging
Maxime CastelliPaul Habert

Abstract

Low-dose chest CT (LDCT) showed high sensitivity and ability to quantify lung involvement of COVID-19 pneumopathy. The aim of this study was to describe the prevalence and risk factors for lung involvement in 247 patients with a visual score and assess the prevalence of incidental findings. For 12 days in March 2020, 250 patients with RT-PCR positive tests and who underwent LDCT were prospectively included. Clinical and imaging findings were recorded. The extent of lung involvement was quantified using a score ranging from 0 to 40. A logistic regression model was used to explore factors associated with a score ≥ 10. A total of 247 patients were analyzed; 138 (54%) showed lung involvement. The mean score was 4.5 ± 6.5, and the mean score for patients with lung involvement was 8.1 ± 6.8 [1-31]. The mean age was 43 ± 15 years, with 121 males (48%) and 17 asymptomatic patients (7%). Multivariate analysis showed that age > 54 years (odds ratio 4.4[2.0-9.6] p < 0.001) and diabetes (4.7[1.0-22.1] p = 0.049) were risk factors for a score ≥ 10. Multivariate analysis including symptoms showed that only age > 54 years (4.1[1.7-10.0] p = 0.002) was a risk factor for a score ≥ 10. Rhinitis (0.3[0.1-0.7] p = 0.005) and anosmia (0.3[0.1-0.9] ...Continue Reading

References

Mar 17, 2004·Respirology : Official Journal of the Asian Pacific Society of Respirology·Gaik Cheng Ooi, Ma Daqing
Mar 18, 2004·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Narinder S PaulGordon L Weisbrod
Jan 16, 2008·Radiology·David M HansellJacques Remy
Jan 25, 2020·The New England Journal of Medicine·Vincent J MunsterEmmie de Wit
Jan 25, 2020·The New England Journal of Medicine·Na ZhuUNKNOWN China Novel Coronavirus Investigating and Research Team
Jan 30, 2020·The New England Journal of Medicine·Qun LiZijian Feng
Feb 28, 2020·The Lancet Infectious Diseases·Heshui ShiChuansheng Zheng
Feb 29, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Xi XuJinxin Liu
Mar 4, 2020·Nature Microbiology·UNKNOWN Coronaviridae Study Group of the International Committee on Taxonomy of Viruses
Mar 7, 2020·Radiology·Wenjie Yang, Fuhua Yan
Mar 17, 2020·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Chih-Cheng LaiPo-Ren Hsueh
Mar 18, 2020·Travel Medicine and Infectious Disease·Jean Christophe LagierPhilippe Brouqui
Mar 18, 2020·AJR. American Journal of Roentgenology·Rui HanDongyou Zhang
Mar 21, 2020·European Radiology·Zhen KangShuchang Zhou
Mar 22, 2020·European Journal of Radiology·Zhoukun LingJinxin Liu
Apr 7, 2020·JAMA : the Journal of the American Medical Association·Giacomo GrasselliUNKNOWN COVID-19 Lombardy ICU Network
Apr 8, 2020·Journal of the American Geriatrics Society·Zainab ShahidRohit Jain
Apr 28, 2020·Radiology·Mathias ProkopUNKNOWN COVID-19 Standardized Reporting Working Group of the Dutch Radiological Society
May 6, 2020·Intensive Care Medicine·Julie HelmsUNKNOWN CRICS TRIGGERSEP Group (Clinical Research in Intensive Care and Sepsis Trial Group for Global Evaluation and Research in Sep
Jul 25, 2020·Thrombosis Research·Antonin TrimailleOlivier Morel
Mar 30, 2021·Radiology. Cardiothoracic Imaging·Ran YangWenbing Zeng
Mar 30, 2021·Radiology. Cardiothoracic Imaging·Shohei InuiYasuhide Uwabe

❮ Previous
Next ❯

Citations

May 25, 2021·Brain, Behavior, & Immunity Health·A BoscuttiP Brambilla
Jul 3, 2021·Journal of Clinical Medicine·Philippe Brouqui On Behalf Of The Ihu Task Force
Jul 25, 2021·Archives of Toxicology·Rachna KapoorGaurav Dhawan

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray
reverse transcription-PCR

Software Mentioned

SS
SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.