Prevalence and Risk Factors for Metabolic Syndrome Among Childhood Acute Lymphoblastic Leukemia Survivors: Experience From South India.

Journal of Pediatric Hematology/oncology
Garima NirmalJagathnath Krishna K M

Abstract

Improved survival of childhood acute lymphoblastic leukemia (ALL) has diverted attention to the long-term consequences of the treatment; metabolic abnormalities being one of the most important issues. Children diagnosed with ALL at age 14 years and younger at Regional Cancer Centre in South India who completed treatment and who were on follow-up for >2 years were enrolled in the study between April 1, 2018 and March 31, 2019. They were prospectively evaluated for the presence of metabolic syndrome (MS) and associated risk factors. A total of 277 survivors of pediatric ALL were recruited during the study period. MS was present in 8.3% (n=23) and 6% (n=13) survivors by National Cholesterol Education Programme Adult Treatment Panel III (NCEPATP III) and International Diabetes Federation (IDF) criteria, respectively. The prevalence of overweight and obesity in the survivors was 9% and 13%. The prevalence of increased waist circumference, low high-density lipoprotein cholesterol, elevated triglycerides, elevated fasting glucose, and increased blood pressure were 10.5%, 28.9%, 24.9%, 2.5%, and 9%, respectively. Overweight/obese survivors were at an increased risk for developing MS (odds ratio=17.66; 95% confidence interval=6.2-50.16,...Continue Reading

References

Sep 27, 2005·Lancet·K George M M AlbertiUNKNOWN IDF Epidemiology Task Force Consensus Group
Sep 29, 2005·Journal of Pediatric Hematology/oncology·Maria KourtiFani Athanassiadou
Jan 30, 2007·Diabetic Medicine : a Journal of the British Diabetic Association·R SinghA Aggarwal
Jun 24, 2008·Leukemia & Lymphoma·Michael E TriggUNKNOWN Children's Oncology Group
Oct 1, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Edward G GarmeyKevin C Oeffinger
Jan 9, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Lillian R MeachamAnn C Mertens
Oct 18, 2011·Indian Journal of Pediatrics·Tanu MidhaUmeshwar Pandey
Jun 12, 2013·Journal of Pediatric Endocrinology & Metabolism : JPEM·Nikhil TandonRaman K Marwaha
Jun 19, 2013·Indian Journal of Endocrinology and Metabolism·Narinder SinghMohd Razaq
Mar 25, 2014·The Journal of Pediatrics·Anuradha KhadilkarSanwar Agarwal
Sep 9, 2016·South Asian Journal of Cancer·Ramandeep Singh Arora, Brijesh Arora
Jan 31, 2018·The American Journal of Clinical Nutrition·Fabiën N BelleClaudia E Kuehni

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Citations

Dec 22, 2021·British Journal of Haematology·Andrea BiondiPeter Hokland

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Software Mentioned

SPSS ( package for social sciences )
WHO anthroplus

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