Prevalence and risk factors of elevated alanine aminotransferase among Korean adolescents: 2001-2014

BMC Public Health
Ju Whi KimJae Sung Ko

Abstract

An elevated alanine aminotransferase (ALT) level is a surrogate marker of non-alcoholic fatty liver disease (NAFLD), the most common liver disorder in adolescents. The majority of previous NAFLD studies in adolescents were performed in selected obese populations or had a cross-sectional design without a time-trend analysis. The purpose of this study was to estimate the prevalence and time trends of elevated ALT levels in a general adolescent population and to identify factors associated with ALT elevation. We analysed data of adolescent participants (aged 10-18 years) from the Korean National Health and Nutrition Examination Survey 2001-2014, a representative sample of the general population in South Korea. Suspected NAFLD was defined as ALT elevation (> 30 U/L) without hepatitis B surface antigen. In all statistical analyses, sampling weight- and design-based data were used. ALT was elevated in 5.3% (standard error: 0.3%) of the study population of adolescent participants (N = 8455). No significant trends were found from 2001 to 2014 in the prevalence of elevated ALT among male and female adolescents. In multiple logistic regression analysis, elevated ALT was independently associated with sex (odds ratio [OR] male versus femal...Continue Reading

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Citations

May 16, 2020·Gastroenterology Research and Practice·Jing ZhangZan Ding
Oct 12, 2018·Korean journal of pediatrics·Eun Jeong Kim, Hyun Jin Kim
May 22, 2019·Pediatric Gastroenterology, Hepatology & Nutrition·Young Hoon ChoJae Sung Ko
Mar 9, 2021·Obesity Science & Practice·Gertraud MaskarinecJohn A Shepherd
Apr 21, 2021·Pediatric Research·José Francisco López-GilAntonio García-Hermoso

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