Prevalence and risk factors of mild chronic renal failure in HIV-infected patients: influence of female gender and antiretroviral therapy

The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases
Marina Pontello CristelliCKD-H. Clinical Investigators

Abstract

In people living with HIV, much is known about chronic kidney disease, defined as a glomerular filtration rate under 60mL/min. However, there is scarce data about prevalence and risk factors for milder impairment (60-89mL/min). The present study aims to assess the influence of sex, antiretroviral therapy, and classical risk factors on the occurrence of mild decreased renal function in a large Spanish cohort of HIV-infected patients. Cross-sectional, single center study, including all adult HIV-1-infected patients under antiretroviral treatment with at least two serum creatinine measures during 2014, describing the occurrence of and the risk factors for mildly decreased renal function (eGFR by CKD-EPI creatinine equation of 60-89mL/min). Among the 4337 patients included, the prevalence rate of mildly reduced renal function was 25%. Independent risk factors for this outcome were age older than 50 years (OR 3.03, 95% CI 2.58-3.55), female sex (OR 1.23, 95% CI 1.02-1.48), baseline hypertension (OR 1.57, 95% CI 1.25-1.97) or dyslipidemia (OR 1.48, 95% CI 1.17-1.87), virologic suppression (OR 1.88, 95% CI 1.39-2.53), and exposure to tenofovir disoproxil-fumarate (OR 1.67, 95% CI 1.33-2.08) or ritonavir-boosted protease-inhibitors (OR...Continue Reading

Citations

Jul 10, 2020·The Journal of Infectious Diseases·Edgar T OvertonChristina M Wyatt
Jul 23, 2020·Revista latino-americana de enfermagem·Priscila Silva PontesRenata Karina Reis
Oct 30, 2020·HIV/AIDS : Research and Palliative Care·Gizachew Ayele ManayeWondwossen Niguse
May 21, 2021·Medicine·Oscar Antonio Garza TovarFrancisco Carlos López Márquez
Sep 21, 2021·AIDS Research and Human Retroviruses·Hillary StiresHélène Hardy

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