Prevalence and risk of thrombophilia defects in vascular patients

European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery
S VigA Halliday

Abstract

This paper reviews the available data on the prevalence of thrombophilia defects in patients with peripheral vascular disease (PVD) and attempts to delineate the risk of failure of vascular intervention in these patients. The prevalence of thrombophilia in stable claudicants is 25% and increases to 40% in those requiring revascularisation, compared to only 11% in the control group. The overall prevalence of thrombophilia defects in patients with premature atherosclerosis appears to be between 15 and 30%. The prevalence in the typical cohort of patients with PVD appears to be similar. All these studies have recruited patients with symptoms significant enough to warrant intervention. The overall prevalence of thrombophilia calculated from these trials, therefore, may not be truly indicative of the general vascular population who may not even present primary or secondary healthcare. The risk of thrombotic occlusion following arterial revascularisation in patients with an identified thrombophilia defect appears to be almost three times that of patients with no evidence of a thrombophilia defect. The best management of these patients has not been determined and needs to be evaluated by prospective randomized trials.

References

Jul 11, 1975·American Journal of Surgery·G J CollinsR Zajtchuk
May 1, 1990·Journal of the American College of Cardiology·T P GavaghanC N Chesterman
Jun 1, 1990·Journal of Vascular Surgery·M C DonaldsonJ A Mannick
Feb 1, 1989·Journal of Vascular Surgery·J Eldrup-JorgensenT H Schwarcz
Jun 1, 1989·European Journal of Vascular Surgery·D C AronsonM A Giesberts
Dec 13, 1986·Lancet·K E MortonC N Chesterman
Jun 1, 1985·Annals of Internal Medicine·A I Schafer
Aug 15, 1995·Thrombosis Research·P GörögI B Kovacs
Jun 1, 1994·The British Journal of Surgery·S A RayJ A Dormandy
Jul 1, 1993·Stroke; a Journal of Cerebral Circulation·D C HessR J Adams
Apr 1, 1997·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·S A RayJ A Dormandy
Nov 5, 1997·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·T G NielsenT V Schroeder
Dec 24, 1997·Progress in Cardiovascular Diseases·A E Schussheim, V Fuster
Jul 27, 2001·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·P J BurnsA W Bradbury
Jul 27, 2001·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·E S Sampram, B Lindblad
Jun 26, 2002·The British Journal of Surgery·H O'GradyA Leahy
Feb 4, 2003·Journal of Vascular Surgery·Michael A CuriLewis B Schwartz
Jun 24, 2003·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·UNKNOWN Peripheral Arterial Diseases Antiplatelet Consensus Group
Nov 1, 1996·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·P B Gorelick
Apr 16, 2009·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Giampaolo P TalamoMaurizio Zangari

❮ Previous
Next ❯

Citations

Feb 16, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Birgitta SalmelaRiitta Lassila
Nov 10, 2013·Annals of Vascular Surgery·Jeffrey D CrawfordGregory L Moneta
Jan 5, 2011·Seminars in Vascular Surgery·Rabih Houbballah, Glenn M LaMuraglia
Apr 17, 2007·Seminars in Hematology·Philippe de Moerloose, Françoise Boehlen
Jun 5, 2012·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·L NiW Ye
Apr 12, 2006·The British Journal of Surgery·S VigA Halliday
Jun 3, 2008·Molecular Biology Reports·Elias KfouryRami Mahfouz
Oct 31, 2007·Tropical Animal Health and Production·Anand PrakashRam Kumar
Apr 22, 2009·AJR. American Journal of Roentgenology·Rüdiger SchernthanerChristian Loewe
Jul 16, 2008·BMC Public Health·Robert M NyarangoBenson O Nyanchongi
Feb 19, 2021·Journal of Vascular Surgery·C Y Maximilian PngAnahita Dua
Feb 9, 2008·Vascular·Ellis S SampramKenneth Ouriel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Aortic Aneurysm

An aortic aneurysm is the weakening and bulging of the blood vessel wall in the aorta. This causes dilatation of the aorta, which is usually asymptomatic but carries the risk of rupture and hemorrhage. Find the latest research on aortic aneurysms here.

Cardiac Aneurysm

Aneurysm refers to a bulge of the wall or lining of a vessel commonly occurring in the blood vessels at the base of the septum or within the aorta. In the heart, it usually arises from a patch of weakened tissue in a ventricular wall, which swells into a bubble filled with blood. Discover the latest research on cardiac aneurysm here.

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

The British Journal of Surgery
G Libertiny, L Hands
Diabetic Medicine : a Journal of the British Diabetic Association
R J TappAusDiab Study Group
© 2022 Meta ULC. All rights reserved