Prevalence and seasonality of common viral respiratory pathogens, including Cytomegalovirus in children, between 0-5 years of age in KwaZulu-Natal, an HIV endemic province in South Africa

BMC Pediatrics
Temitayo FamorotiThumbi Ndung'u

Abstract

Acute respiratory tract infections contribute significantly to morbidity and mortality among young children in resource-poor countries. However, studies on the viral aetiology of acute respiratory infections, seasonality and the relative contributions of comorbidities such as immune deficiency states to viral respiratory tract infections in children in these countries are limited. A retrospective analysis of laboratory test results of upper or lower respiratory specimens of children between 0 and 5 years of age collected between 1st January 2011 and 31st July 2015 from hospitals in KwaZulu-Natal, South Africa. Respiratory specimens were tested for viral respiratory pathogens using multiplex polymerase chain reaction (PCR), HIV testing was performed either by serological or PCR methods. Cytomegalovirus (CMV) respiratory infection was determined using the CMV R-gene PCR kit. In total 2172 specimens were analysed, of which 1175 (54.1%) were from males. The median age was 3.0 months (interquartile range [IQR] 1-7). Samples from the lower respiratory tract accounted for 1949 (89.7%) of all specimens. Respiratory multiplex PCR results were positive in 834 (45.7%) specimens. Respiratory syncytial virus (RSV) was the most commonly dete...Continue Reading

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Citations

Apr 25, 2020·Pathogens·Ravendra P ChauhanMohamed E El Zowalaty
Jan 26, 2021·Influenza and Other Respiratory Viruses·Daniel R L GreiffHannah C Moore
Aug 28, 2021·Biology·Irina Kiseleva, Andrey Ksenafontov
Sep 3, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Caitriona MurphyChristopher J Gill
Nov 24, 2021·Future Microbiology·Kerusha GovenderRaveen Parboosing

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Methods Mentioned

BETA
PCR
ELISA

Software Mentioned

SPSS

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