Prevalence and trends of cellulosics in pharmaceutical dosage forms

Drug Development and Industrial Pharmacy
David J Mastropietro, Hossein Omidian

Abstract

Many studies have shown that cellulose derivatives (cellulosics) can provide various benefits when used in virtually all types of dosage forms. Nevertheless, the popularity of their use in approved drug products is rather unknown. This research reports the current prevalence and trends of use for 15 common cellulosics in prescription drug products. The cellulosics were powdered and microcrystalline cellulose (MCC), ethyl cellulose, hydroxypropyl cellulose (HPC), hydroxyethyl cellulose (HEC), hypromellose (HPMC), HPMC phthalate, HPMC acetate succinate, cellulose acetate (CA), CA phthalate, sodium (Na) and calcium (Ca) carboxymethylcellulose (CMC), croscarmellose sodium (XCMCNa), methyl cellulose, and low substituted HPC. The number of brand drug products utilizing each cellulosics was determined using the online drug index Rxlist. A total of 607 brand products were identified having one or more of the cellulosics as an active or inactive ingredient. An array of various dosage forms was identified and revealed HPMC and MCC to be the most utilized cellulosics in all products followed by XCMCNa and HPC. Many products contained two or more cellulosics in the formulation (42% containing two, 23% containing three, and 4% containing 4-...Continue Reading

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Citations

Feb 8, 2014·Drug Development and Industrial Pharmacy·Elisabeth PeetersJean-Paul Remon
Jun 12, 2014·Drug Development and Industrial Pharmacy·Federica BigucciBarbara Luppi
Nov 28, 2013·Drug Development and Industrial Pharmacy·Alvaro Goyanes, Ramón Martínez-Pacheco
Sep 26, 2015·International Journal of Pharmaceutics·Thanh Huong Hoang ThiMarie-Pierre Flament

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