Prevalence and type distribution of human papillomavirus in women with cervical lesions in Liaoning Province, China

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Xia LiuYao Zhang

Abstract

Type-specific persistence of human papillomavirus (HPV) infection can cause invasive cervical cancer. The distribution and prevalence of HPV genotypes depend on the geographic region and on demographic factors. This study aimed to investigate the prevalence and distribution of HPV genotypes in uterine cervical lesions in Liaoning Province, China. A total of 1444 cervical swabs from patients with cervical cancer (CC, n = 134), cervical intraepithelial neoplasia (CIN) II/III (n = 517), and CIN I (n = 180) were detected for HPV genotypes using the PGMY09/11 primer system and HPV GenoArray test (HybriBio Ltd., Hong Kong). Age-matched samples of 613 women without cervical neoplasia were analyzed as control. The prevalence of HPV was 82.84% in CC, 89.56% in CIN II/III, 70.56% in CIN I, and 44.70% in control. The 5 leading genotypes in CIN II/III were, in descending order of prevalence, HPV types 16 (61.12%), 58 (14.12%), 33 (13.93%), 31 (8.32%), and 52(6.27%); whereas HPV types 16 (73.13%), 18 (7.46%), 58 (3.73%), and 31/33/39 (all were 2.24%) were in CC. Multiple HPV infections comprising 2 to 5 types were found in 17.59% of the patients. Human papillomavirus 16 was the predominant genotype in all categories. The prevalence of both ...Continue Reading

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Citations

Mar 27, 2018·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Shuang SuiKaichun Zhu
Mar 26, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Zhengrong SunQiang Ruan
May 25, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Zhengrong SunQiang Ruan
Nov 26, 2010·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Jinke LiLina Hu
May 6, 2014·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Heng WeiShulan Zhang
Apr 1, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Qiu-Xiang Xu, Zhen-Yu Zhang
Apr 14, 2021·Journal of Medical Virology·Xiaoyan ZhuJianrong Su

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