DOI: 10.1101/496919Dec 14, 2018Paper

Prevalence, Characteristics, and Clinical Significance of Concomitant Cardiomyopathies in Subjects with Bicuspid Aortic Valve

BioRxiv : the Preprint Server for Biology
Hyeonju JeongJong-Won Ha

Abstract

Background: In this study, the prevalence, characteristics, and clinical significance of concomitant specific cardiomyopathies (CMs) were investigated in subjects with bicuspid aortic valve (BAV). Methods: We retrospectively evaluated 1,186 adults with BAV (850 males, mean age 56 ± 14 years). Left ventricular noncompaction (LVNC), hypertrophic CM (HCM), and idiopathic dilated CM (DCM) were diagnosed when patients fulfilled current clinical and echocardiographic criteria. Clinical and echocardiographic characteristics including comorbidities, heart failure presentation, BAV morphology, function, and aorta phenotypes in BAV subjects with or without specific CM were compared. Results: Overall, 67 subjects (5.6 %) had concomitant CMs: 40 (3.4%) patients with LVNC, 17 (1.4%) with HCM, and 10 (0.8%) with DCM. BAV subjects with HCM had a higher prevalence of diabetes mellitus, heart failure with preserved ejection fraction (HFPEF), and tended to have type 0 phenotype, while BAV subjects with DCM showed a higher prevalence of chronic kidney disease and heart failure with reduced ejection fraction (HFREF). BAV subjects with LVNC were significantly younger, predominantly male, and had greater BAV dysfunction and a higher prevalence of no...Continue Reading

Related Concepts

Aorta
Diabetes Mellitus
Echocardiography
Heart Failure
Hypertrophy
Takayasu Arteritis
Research Subject
Bicuspid Aortic Valve
Myocytes, Cardiac
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