Prevalence, Determinants, and Prognostic Significance of Hospital Acquired Pneumonia in Patients with Acute Heart Failure

Journal of Clinical Medicine
Atsushi TadaToshihisa Anzai

Abstract

The prognostic impact of hospital-acquired pneumonia (HAP) in acute heart failure (AHF) patients have not been fully elucidated. We evaluated 776 consecutive hospitalized AHF patients. The primary in-hospital outcomes were all-cause death and worsening heart failure (WHF), while the outcome following discharge was all-cause death. The clinical diagnosis of HAP was based on clinical practice guidelines by the Infectious Diseases Society of America and the American Thoracic Society. Patients with HAP had a significantly higher incidence of in-hospital death (12% vs. 1%, p < 0.001), WHF during the hospitalization (28% vs. 7%, p < 0.001), and longer length of hospital stay (p = 0.003) than those without. Among patients who survived at discharge, during a median follow-up period of 741 (interquartile range 422-1000) days, the incidence of all-cause death was significantly higher in patients with HAP than in those without (p < 0.001). In the multivariable Cox regression, HAP development was independently associated with all-cause death after discharge (HR [hazard ratio] 1.86, 95%CI [confidence interval] 1.08-3.19). Furthermore, older age (OR [odds ratio] 1.04, 95%CI 1.01-1.08), male sex (OR 2.21, 95%CI 1.14-4.28), and higher serum wh...Continue Reading

References

Dec 23, 1971·The New England Journal of Medicine·P A McKeeW B Kannel
Jan 13, 2004·Journal of the American College of Cardiology·Daniel E FormanHarlan M Krumholz
Jan 18, 2005·Chest·Nieves SopenaUNKNOWN Neunos 2000 Study Group
Feb 9, 2005·American Journal of Respiratory and Critical Care Medicine·UNKNOWN American Thoracic Society, UNKNOWN Infectious Diseases Society of America
Aug 19, 2007·Circulation·M W Merx, C Weber
Mar 29, 2008·American Journal of Respiratory and Critical Care Medicine·Sachin YendeUNKNOWN GenIMS Investigators
Jan 16, 2009·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Coleman RotsteinGeorge G Zhanel
Oct 12, 2010·The New England Journal of Medicine·Barry M MassieUNKNOWN PROTECT Investigators and Committees
Jan 25, 2012·The American Journal of Medicine·Naga V A KommuriScott L Hummel
Nov 13, 2012·Lancet·John R TeerlinkUNKNOWN RELAXin in Acute Heart Failure (RELAX-AHF) Investigators
Jan 22, 2013·Lancet·Vicente F Corrales-MedinaJulio A Chirinos
Aug 30, 2013·The New England Journal of Medicine·Derek C Angus, Tom van der Poll
Mar 14, 2014·JACC. Heart Failure·Eugene Braunwald
Mar 29, 2014·The New England Journal of Medicine·Shelley S MagillUNKNOWN Emerging Infections Program Healthcare-Associated Infections and Antimicrobial Use Prevalence Survey Team
Dec 19, 2014·Circulation·Dariush MozaffarianUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Jan 21, 2015·JAMA : the Journal of the American Medical Association·Vicente F Corrales-MedinaSachin Yende
Jul 30, 2015·European Journal of Heart Failure·Hiroaki ShimokawaYasuhiko Sakata
Apr 30, 2016·European Journal of Heart Failure·Toshiyuki NagaiUNKNOWN NaDEF investigators
Nov 30, 2016·Antimicrobial Resistance and Infection Control·Leonor PássaroCaroline Landelle
Jul 19, 2017·Stroke; a Journal of Cerebral Circulation·Christoph PalliThomas Gattringer
Oct 21, 2017·American Journal of Infection Control·Karen K GiulianoBarbara Quinn
May 10, 2018·Intensive Care Medicine·R T MankowskiD C Angus
May 24, 2018·Journal of Cachexia, Sarcopenia and Muscle·Riyo KomatsuMasakazu Ichinose
Jun 9, 2018·Stroke; a Journal of Cerebral Circulation·Yasuhiro HamataniUNKNOWN NaDEF Investigators
Jan 16, 2020·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Cristine C LacernaDavid Witt

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Citations

Jan 18, 2021·The American Journal of Cardiology·Hidehiro KanekoIssei Komuro

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