Prevalence, Distribution, and Development of an Ecological Niche Model of Dermacentor variabilis Ticks Positive for Rickettsia montanensis

Vector Borne and Zoonotic Diseases
Heidi K St JohnAllen L Richards

Abstract

Rickettsia montanensis has long been considered a nonpathogenic member of the spotted fever group rickettsiae. However, the infection potential of R. montanensis is being revisited in light of its recent association with a case of human infection in the United States and the possibility that additional cases may have been misdiagnosed as Rocky Mountain spotted fever. To this end, DNA was extracted from American dog ticks (Dermacentor variabilis) removed from Department of Defense (DoD) personnel and their dependents at DoD medical treatment facilities (MTFs) during 2002-2012 (n = 4792). These 4792 samples were analyzed for the presence of R. montanensis (n =  36; 2.84%) and all vector DNA was confirmed to be of D. variabilis origin using a novel Dermacentor genus-specific quantitative real-time polymerase chain reaction procedure, Derm, and a novel Dermacentor species multilocus sequence typing assay. To assess the risk of R. montanensis infection, the positive and negative samples were geographically mapped utilizing MTF site locations. Tick localities were imported into a geographical information systems (GIS) program, ArcGIS, for mapping and analysis. The ecological niche modeling (ENM) program, Maxent, was used to estimate ...Continue Reading

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Citations

Oct 3, 2018·Tropical Medicine and Infectious Disease·Melissa Hardstone Yoshimizu, Sarah A Billeter
Oct 3, 2018·Tropical Medicine and Infectious Disease·Alison Luce-FedrowAllen L Richards
Dec 3, 2020·PLoS Neglected Tropical Diseases·Hualei XinZhongjie Li

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Datasets Mentioned

BETA
FN296278

Methods Mentioned

BETA
PCR
Fluorescence

Software Mentioned

Raster Calculator
ArcGIS
Google Maps
SmartCycler
Maxent
DistancesFrom
Excel
WorldClim
Beacon Design

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