Prevalence estimates for pemphigoid in the United States: A sex-adjusted and age-adjusted population analysis

Journal of the American Academy of Dermatology
Sara WertenteilAllireza Alloo

Abstract

The burden of the pemphigoid group of autoimmune blistering diseases is poorly understood. To estimate standardized overall and sex-specific, age-specific, and race-specific prevalence estimates for pemphigoid among adults in the United States. Cross-sectional analysis of electronic health records data for a demographically heterogeneous population-based sample of >55 million patients across all 4 census regions. Overall pemphigoid prevalence was 0.012%, or 12 pemphigoid patients/100,000 adults. Prevalence of pemphigoid among those aged ≥60 years was 0.038%, or 37.7 cases/100,000 adults. Prevalence increased ∼2-fold within each successive age group and was highest among patients aged ≥90 years (123.6 [95% CI 115.2-132.5] cases/100,000 adults). Adjusted prevalence in women was 12.7 (95% CI 12.3-13.2) cases/100,000 adults, slightly more than that in men (11.0 [95% CI 10.5-11.6] cases/100,000 adults). Adjusted prevalences were similar for blacks (15.4 [95% CI 14.0-17.0] cases/100,000 adults) and whites (13.5 [95% CI 13.0-13.9] cases/100,000 adults). Analysis of electronic health data might result in disease misclassification. Pemphigoid is rare in the United States. Patients aged ≥60 years comprise the majority of cases.

Citations

Jul 22, 2018·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Nancy J DevlinBen van Hout
Jan 9, 2020·Diagnosis·Ashley M ReeseAlex G Ortega-Loayza
Oct 23, 2019·Frontiers in Immunology·Kelly N MessinghamJanet A Fairley
Aug 8, 2020·Dermatology : International Journal for Clinical and Investigative Dermatology·Meghan L McPhieMark G Kirchhof
Jul 31, 2019·International Journal of Women's Dermatology·Aslı Bilgic-TemelDedee F Murrell

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